Author | Silva, Milca de Jesus | |
Author | Santana, Maria Borges Rabelo de | |
Author | Tosta, Bruna R. | |
Author | Espinheira, Roberta Pereira | |
Author | Neves, Neuza Maria Alcantara | |
Author | Barreto, Maurício Lima | |
Author | Figueiredo, Camila Alexandrina | |
Author | Costa, Ryan dos Santos | |
Access date | 2019-09-27T18:59:41Z | |
Available date | 2019-09-27T18:59:41Z | |
Document date | 2019 | |
Citation | SILVA, Milca de Jesus et al. Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population. Allergy, Asthma & Clinical Immunology, v. 15, p. 1-12, 2019. | pt_BR |
ISSN | 1710-1484 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35980 | |
Sponsorship | National Research Ethics Committee
(reference number: 120.616) and free informed consent was properly
obtained from the parents or legal guardian of each child. | pt_BR |
Language | eng | pt_BR |
Publisher | BMC | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Asma | pt_BR |
Subject in Portuguese | Atopia | pt_BR |
Subject in Portuguese | Variantes | pt_BR |
Subject in Portuguese | IL-17 | pt_BR |
Title | Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s13223-019-0340-7 | |
Abstract | Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The TH17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. The aim of our study was to evaluate the association between genetic variants in IL17 pathway genes with asthma and atopy markers. Materials and methods: Genotyping was performed using a commercial panel in 1245 participants of SCAALA
cohort. The study included 91 SNVs in IL-17 pathway genes. Logistic regressions for asthma and atopy markers were
performed using PLINK 1.9. In silico analyses were performed using rSNPbase, RegulomeDB, and Gtex portal for in
silico gene expression.
Results and discussion: The T allele of rs1974226 in IL17A was positively associated with asthma (OR: 1.37; 95% CI
1.02–1.82). Also, the T allele of rs279548 was positively associated with asthma (OR: 1.30; 95% CI 1.02–1.64), atopy (OR:
1.62; 95% CI 1.05–2.50) and increased expression of the IL17RC in lung and whole blood tissues. The others genetic
variants in the IL17 pathways genes were associated with both protection and risk for asthma development as well as
with IgE levels.
Conclusion: The genetic variants in IL-17-related genes are associated with the atopic asthma phenotype and IgE
production. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
Subject | Asthma | pt_BR |
Subject | Atopy | pt_BR |
Subject | Variants | pt_BR |
Subject | IL-17 genes | pt_BR |