Author | Araujo, Abelardo Q-C. | |
Access date | 2019-08-16T14:03:38Z | |
Available date | 2019-08-16T14:03:38Z | |
Document date | 2015 | |
Citation | ARAUJO, Abelardo Q-C. Update on neurological manifestations of HTLV-1 infection. Current Infectious Disease Reports, v. 17, p. 1-7, 2015. | pt_BR |
ISSN | 1523-3847 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34853 | |
Language | eng | pt_BR |
Publisher | Springer | pt_BR |
Rights | open access | pt_BR |
Title | Update on neurological manifestations of HTLV-1 infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s11908-014-0459-0 | |
Abstract | The human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects 10–20 million persons around the world. Initially associated with the hematological malignancy adult T cell leukemia/lymphoma (ATLL), HTLV-1 is also the cause of a chronic progressive myelopathy named “HTLV-1-associated myelopathy/tropical spastic paraparesis” (HAM/TSP). HAM/TSP arises as the tip of the iceberg of an assortment of neurological syndromes triggered by the virus such as inflammatory myopathies, polyneuropathies, amyotrophic lateral sclerosis (ALS)-like syndromes, dysautonomia, and cognitive impairment. HAM/TSP typifies a chronic progressive spastic paraparesis with neurogenic bladder and minimal sensory signs. The neuropathology of HAM/TSP is concentrated in the thoracic spinal cord and is typically biphasic. Initially, there is a perivascular lymphocytic cuffing and mild parenchymal mononuclear infiltrates. Subsequently, this is replaced by gliosis and scarring. The neuropathogenesis of HTLV-1 is still partially understood. At present, the therapy of HAM/TSP remains basically symptomatic. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HTLV-1-associated myelopathy/tropical spastic paraparesis | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Myelopathy | pt_BR |
Subject | Myelitis | pt_BR |
Subject | Polymyositis | pt_BR |
Subject | Polyneuropathy | pt_BR |
e-ISSN | 1523-3847 | |
Embargo date | 2020-08-16 | |