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https://www.arca.fiocruz.br/handle/icict/34646
REVISITING KERATOCONJUNCTIVITIS SICCA ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1: PREVALENCE, CLINICAL ASPECTS AND PROVIRAL LOAD
Author
Affilliation
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.
Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil.
Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.
Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil.
Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil.
Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.
Abstract
The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohortof HTLV-1-infected individuals living in Salvador, Brazil.Methods: A cross-sectional study was conducted between June 2004 and September 2017 atthe Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from758 HTLV-1-infected patients was collected. A complete ophthalmologic examination wasperformed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengaland Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out ofthree positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regressionwith robust error variance.Results: The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR: 1.84; CI95%:1.50–2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjustedPR: 1.63; CI95%: 1.31–2.02). Proviral load, low corrected visual acuity, burning and/or pain anditching were all significantly higher in patients with KCS.
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