Author | Kasprowicz, Victoria | |
Author | Schulze Zur Wiesch, Julian | |
Author | Kuntzen, Thomas | |
Author | Nolan, Brian E. | |
Author | Longworth, Steven | |
Author | Berical, Andrew | |
Author | Blum, Jenna | |
Author | McMahon, Cory | |
Author | Reyor, Laura L. | |
Author | Elias, Nahel | |
Author | Kwok, William W. | |
Author | McGovern, Barbara G. | |
Author | Freeman, Gordon | |
Author | Chung, Raymond T. | |
Author | Klenerman, Paul | |
Author | Lewis-Ximenez, Lia | |
Author | Walker, Bruce D. | |
Author | Allen, Todd M. | |
Author | Kim, Arthur Y. | |
Author | Lauer, Georg M. | |
Access date | 2019-07-16T15:58:01Z | |
Available date | 2019-07-16T15:58:01Z | |
Document date | 2008 | |
Citation | KASPROWICZ, Victoria et al. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome. Journal of Virology, v. 82, n. 6, p. 3154-3160, Mar. 2008. | pt_BR |
ISSN | 0022-538X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34159 | |
Description | AUTHOR’S CORRECTION
High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and
CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
Victoria Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth,
Andrew Berical, Jenna Blum, Cory McMahon, Laura L. Reyor, Nahel Elias, William W. Kwok,
Barbara G. McGovern, Gordon Freeman, Raymond T. Chung, Paul Klenerman, Lia Lewis-Ximenez,
Bruce D. Walker, Todd M. Allen, Arthur Y. Kim, and Georg M. Lauer
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 6th Floor, Room 6001,
Charlestown, Massachusetts 02129-2000; Med. Klinik I, Universita¨t Hamburg, Germany; Transplantation Unit, Department of
Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114; Benaroya Research Institute at Virginia Mason, Seattle,
Washington; Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts; Department of
Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115;
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114;
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford,
South Parks Road, Oxford OX1 3SY, United Kingdom; Departmento de Virologia,
Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil; and Howard | en |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Vírus da hepatite C | pt_BR |
Subject in Portuguese | Infecção aguda | pt_BR |
Subject in Portuguese | Células CD8 | pt_BR |
Subject in Portuguese | Cédulas CD4 | pt_BR |
Subject in Portuguese | Células T | pt_BR |
Subject in Portuguese | Expressão de PD-1 | pt_BR |
Title | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/JVI.02474-07 | |
Abstract | We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Med. Klinik I, Universitát Hamburg. Germany / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Transplantation Unit, Department of Surgery, Massachusetts General Hospital. Boston, Massachusetts. USA. | pt_BR |
Affilliation | Benaroya Research Institute at Virginia Mason. Seattle, Washington, USA. | pt_BR |
Affilliation | Lemuel Shattuck Hospital. Tufts University School of Medicine. Boston, Massachusetts, USA. | pt_BR |
Affilliation | Department of Medical Oncology, Dana-Farber Cancer Institute / Department of Medicine, Harvard Medical School. Boston, Massachusetts, USA. | pt_BR |
Affilliation | Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital. Boston, Massachusetts, USA / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA. | pt_BR |
Affilliation | Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford. Oxford, United Kingdom. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA / Howard Hughes Medical Institute. Chevy Chase, Maryland, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Affilliation | Partners AIDS Research Center. Massachusetts General Hospital. Harvard Medical School. Charlestown, Massachussets, USA. | pt_BR |
Subject | Hepatitis C virus | pt_BR |
Subject | Acute HCV Infection | pt_BR |
Subject | PD-1 Expression | pt_BR |
Subject | T cells | pt_BR |
Subject | CD8 | pt_BR |
Subject | CD4 | pt_BR |
e-ISSN | 1098-5514 | |