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https://www.arca.fiocruz.br/handle/icict/33980
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- INI - Artigos de Periódicos [3394]
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PERFORMANCE OF CRYPTOCOCCAL ANTIGEN LATERAL FLOW ASSAY IN SERUM, CEREBROSPINAL FLUID, WHOLE BLOOD, AND URINE IN HIV-INFECTED PATIENTS WITH CULTURE-PROVEN CRYPTOCOCCAL MENINGITIS ADMITTED AT A BRAZILIAN REFERRAL CENTER
Cryptococcosis
Diagnosis
Human immunodeficiency virus
Acquired immunodeficiency syndrome
Author
Affilliation
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
University of Minnesota. Minneapolis, MN, USA.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Universidade Federal de São Paulo. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.
Instituto de Infectologia Emilio Ribas. São Paulo, SP, Brasil.
University of Minnesota. Minneapolis, MN, USA.
Abstract
Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay (LFA) in serum, CSF, whole blood (fingerstick), and fresh urine. In addition, HIV-infected patients with other neurological confirmed diseases were included in order to evaluate the specificity of CrAg LFA in serum. Twenty patients with cryptococcal meningitis were included and in 19 of them, CrAg LFA in CSF, serum, and whole blood were positive (95% sensitivity). In 18 patients, India ink test was positive in CSF (90% sensitivity), and in 16 cases, CrAg LFA was positive in urine (80% sensitivity). Thirty-six HIV-infected patients with other neurological diseases had negative results of CrAg LFA in serum (100% specificity). In conclusion, CrAg LFA in serum, CSF, and whole blood showed high sensitivity and specificity. Whole blood CrAg LFA seems to be a good and reliable strategy to improve AIDS-related cryptococcal meningitis diagnosis in Brazil.
Keywords
Cryptococcal meningitisCryptococcosis
Diagnosis
Human immunodeficiency virus
Acquired immunodeficiency syndrome
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