Author | Lepelletier, Yves | |
Author | Smaniotto, Salete | |
Author | Hadj-Slimane, Réda | |
Author | Villa-Verde, Déa Maria Serra | |
Author | Nogueira, Ana Cristina | |
Author | Dardenne, Mireille | |
Author | Herminie, Olivier | |
Author | Savino, Wilson | |
Access date | 2019-07-04T13:42:19Z | |
Available date | 2019-07-04T13:42:19Z | |
Document date | 2007 | |
Citation | LEPELLETIER, Yves et al. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. PNAS, v. 104, n. 13, p. 5545-5550, Mar. 2007. | pt_BR |
ISSN | 0027-8424 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33836 | |
Language | eng | pt_BR |
Publisher | National Academy of Sciences | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Matriz Extracelular | pt_BR |
Subject in Portuguese | Adesão e migração de timócitos | pt_BR |
Subject in Portuguese | Integrinas | pt_BR |
Title | Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions | pt_BR |
Type | Article | pt_BR |
DOI | 10.1073/pnas.0700705104 | pt_BR |
Abstract | It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in both cortex and medulla of thymic lobules, being found in distinct CD4/CD8-defined thymocyte subsets. NP-1 is also found in thymic epithelial cells (TEC) in situ and in vitro, and is recruited at the site of TEC–thymocyte contact. Moreover, NP-1 was rapidly
up-regulated during thymocyte stimulation by T cell receptor (TCR) and IL-7 or after adhesion to TEC. Semaphorin-3A (Sema-3A), a natural ligand of NP-1, is also present in human thymus, both in TEC and thymocytes, being up-regulated in thymocytes after TCR engagement. Functionally, Sema-3A decreases the adhesion capacity of NP-1 thymocytes and induces their migration by a repulsive effect. In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development. | pt_BR |
Affilliation | Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Alagoas. Departamento de Morfologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Université Paris V René Descartes. Institut National de la Santé et de la Recherche Médicale Unité 648. Paris, France / TRAGEX Pharma. Tour Reflets. 75015 Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France. | pt_BR |
Affilliation | Université René Descartes Paris V. Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147. Paris, France. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / | pt_BR |
Subject | Extracellular matrix | pt_BR |
Subject | Integrins | pt_BR |
Subject | Thymocyte adhesion and migration | pt_BR |
DeCS | Integrinas | pt_BR |
e-ISSN | 1091-6490 | |