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2030-01-01
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- IOC - Artigos de Periódicos [12488]
- MG - IRR - Artigos de Periódicos [4049]
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IN SILICO ANALYSIS OF PUTATIVE DORMANCY GENES IN PLASMODIUM VIVAX
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Fundação Oswaldo Cruz. Instituto René Rachou. Biologia Molecular e Imunologia da Malária Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas e Genômica. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós Graduação em Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas e Genômica. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Biologia Molecular e Imunologia da Malária Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas e Genômica. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós Graduação em Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas e Genômica. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Biologia Molecular e Imunologia da Malária Belo Horizonte, MG, Brasil.
Abstract
Plasmodium vivax is the most widely spread species causing human malaria. The control of malaria caused by P. vivax has been largely hampered by its ability to develop a dormant liver stage that can generate a new blood infection at different periods of time. Unfortunately, the mechanisms of dormancy in P. vivax have not been thoroughly elucidated to date. In this study, the putative dormancy genes were analyzed to select genes with less genetic variability to maintain the function of relapsing. Expression data concerning these genes were searched to support the selection. Protein interactions among selected gene products were identified based on known and predicted protein-protein interaction using String database. Potentially interacting proteins (n = 15) were used to propose a mechanism involved in dormancy based on the differential vesicular transport due to the iron available in the hepatocyte.
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