Author | Teixera, Leda Fabiélen | |
Author | Carvalho, Letícia Helena de | |
Author | Castro, Onássis Boeri de | |
Author | Bastos, Jéssica Silva Félix | |
Author | Néry, Neriane Monteiro | |
Author | Oliveira, George Azevedo | |
Author | Kayano, Anderson Makoto | |
Author | Soares, Andreimar Martins | |
Author | Zuliani, Juliana Pavan | |
Access date | 2019-06-10T19:58:07Z | |
Available date | 2019-06-10T19:58:07Z | |
Document date | 2017 | |
Citation | TEIXEIRA, Leda Fabiélen et al. Local and systemic effects of BdipTX-I, a Lys-49 phospholipase A2 isolated from Bothrops diporus snake venom. Toxicon, v. 141, p. 55-64, 2017. | pt_BR |
ISSN | 0041-0101 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33448 | |
Description | O artigo encontra-se disponível para download no site do Editor. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Local and systemic effects of BdipTX-I, a Lys-49 phospholipase A2 isolated from Bothrops diporus snake venom | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.toxicon.2017.11.007 | pt_BR |
Abstract | The present work aimed to isolate a basic phospholipase A2 (PLA2) from Bothrops diporus snake venom (BdV), evaluate and compare the myotoxic and oedema-inducing activities, as well as the systemic effects caused by both the isolated PLA2 and BdV on Swiss mice. A Lys-49 PLA2 (BdipTX-I) was obtained through two chromatographic steps: an ion-exchange and a reverse phase. The local (oedema and myotoxicity) and systemic (hepatic and renal functions) effects were then assessed for BdipTX-I and BdV. Results showed that the oedema-inducing activity was significant in all tested doses (5 and 20 mg/paw) for both BdipTX-I and BdV. Myotoxicity was evaluated by the increase of serum CK, CK-MB and LDH, and results
showed that BdV effect is more prominent than BdipTX-I effect. The systemic effects were evaluated by determining specific laboratory markers: AST, ALT, GGT, ALP, urea, creatinine, protein and calcium. BdipTX-I and BdV were able to induce renal changes in the experimental model, leading to proteinuria (induced both by BdipTX-I and by BdV) and uremia (induced only by BdV). Thus, it is concluded that the systemic effects of BdV and BdipTX-I occur differently. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Biomoléculas Aplicadas à Saúde. Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Biomoléculas Aplicadas à Saúde. Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Biomoléculas Aplicadas à Saúde. Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brasil / Centro Universitário São Lucas. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Imunologia Celular Aplicada à Saúde. Porto Velho, RO, Brasil / Fundação Oswaldo Cruz. Centro de Biomoléculas Aplicadas à Saúde. Universidade Federal de Rondônia. Departamento de Medicina. Porto Velho, RO, Brasil. | pt_BR |
Subject | Phospholipase A2 | pt_BR |
Subject | Bothrops diporus | pt_BR |
Subject | Oedema | pt_BR |
Subject | Myotoxicity | pt_BR |
Subject | Systemic effect | pt_BR |
e-ISSN | 1879-3150 | |