Author | Garcia, Juberlan S. | |
Author | Hooper, Cleber S. | |
Author | Simões, Raquel O. | |
Author | Santos, Marcos Antônio J. dos | |
Author | Maldonado Jr., Arnaldo | |
Author | Pinheiro, Jairo | |
Access date | 2019-05-23T17:54:26Z | |
Available date | 2019-05-23T17:54:26Z | |
Document date | 2011 | |
Citation | GARCIA, Juberlan S. et al. Biochemical and histological responses of Rattus novergicus (Wistar) infected by Echinostoma paraensei (Trematoda: Echinostomatidae). Veterinary Parasitology, v. 178, p. 86-92, 2011. | pt_BR |
ISSN | 0304-4017 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33202 | |
Language | eng | pt_BR |
Publisher | Elsevier 12 Months | pt_BR |
Rights | open access | |
Subject in Portuguese | Aminotransferases | pt_BR |
Subject in Portuguese | Função hepática | pt_BR |
Subject in Portuguese | Bilirrubina | pt_BR |
Subject in Portuguese | Albuminas | pt_BR |
Subject in Portuguese | Globulinas | pt_BR |
Title | Biochemical and histological responses of Rattus novergicus (Wistar) infected by Echinostoma paraensei (Trematoda: Echinostomatidae) | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.vetpar.2010.12.040 | |
Abstract | Tests were performed to evaluate the biochemical alterations in Rattus norvegicus after infection by the intestinal trematode Echinostoma paraensei. The rodents received 150 metacercariae each, serum samples were collected and the parasite load was quantified weekly until the fifth week of infection. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALKP), gamma-glutamyl transferase (GGT), bilirubin, glucose, total proteins and fractions and hepatic glycogen were determined. All the animals exposed to the metacercariae were infected in the first week and worms were recovered up to the third week after infection. The levels of AST, ALT, GGT, bilirubin and globulin rose in the first and/or second week and declined thereafter to levels near those of the control group. In contrast, the level of total proteins in the plasma fell significantly in the first week while the ALKP activity went down only in the fourth and fifth weeks in relation to the control group. There was no significant difference in the levels of albumin, glycogen and glucose. Infection by E. paraensei in R. norvegicus causes changes in the hepatic function, possibly resulting from the cholestasis produced by the partial obstruction of the bile duct by the helminths. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Curso de Pós-Graduação em Ciências Veterinárias. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Departamento de Controle de Qualidade Animal. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Criação de Animais de Laboratório. Departamento de Controle de Qualidade Animal. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Biologia Animal. Seropédica, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Biologia. Departamento de Ciências Fisiológicas. Seropédica, RJ, Brasil. | pt_BR |
Subject | Hepatic function | pt_BR |
Subject | Aminotransferases | pt_BR |
Subject | ALKP | pt_BR |
Subject | Bilirubin | pt_BR |
Subject | Globulin | pt_BR |
Subject | Albumin | pt_BR |
e-ISSN | 1873-2550 | |