Author | Almeida, Renata dos Santos | |
Author | Ramos, Alessandra Maria de Luna | |
Author | Luna, Carlos Feitosa | |
Author | Pedrosa, Francisco | |
Author | Donadi, Eduardo Antônio | |
Author | Lucena-Silva, Norma | |
Access date | 2019-05-23T13:48:52Z | |
Available date | 2019-05-23T13:48:52Z | |
Document date | 2018 | |
Citation | ALMEIDA, Renata dos Santos et al. Cytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemia. Cytokine, v. 102, p. 94-101, 1 Feb. 2018. | pt_BR |
ISSN | 1096-0023 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33193 | |
Sponsorship | FACEPE (APQ-0040-4.00 / 13) e CAPES (PROCAD-177382 / 2013grant). Dra. Lucena-Silva é bolsista do CNPq (CNPq 310364 / 2015-9) e Renata S. Almeida da FundaçãoOswaldo Cruz (FIOCRUZ). | pt_BR |
Language | eng | pt_BR |
Rights | restricted access | pt_BR |
Title | Cytokines and soluble HLA-G levels in bone marrow stroma and their association with the survival rate of patients exhibiting childhood T-cell acute lymphoblastic leukemia | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.cyto.2017.07.014 | |
Abstract | Leukemic cells can induce defective expression of soluble factors and change marrow cytokine profile, leading to aberrant cell signaling, cell fixation and cell proliferation in bone marrow. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder which accounts for 15% of pediatric ALL. To evaluate the contribution of immunological factors on T-ALL survival, we measured Th1, Th2, Th17 cytokines and soluble HLA-G (sHLA-G) levels in bone marrow from 32 Brazilian children at diagnosis (D0), after induction (D19) and after consolidation (D49) of the chemotherapy phase. Data were analyzed using non-parametric tests, and survival rates were evaluated by Kaplan-Meier method (log-rank test). TNF, IL-10 and IL-6 levels were increased at diagnosis compared to D19 and D49. IL-10 levels<4.57pg/mL at diagnosis were associated with increased survival rate, in presence of positive correlation between IL-2 and IL-17 levels. Increased survival rate was also associated with IFN-γ levels<1.17pg/mL at D49, with a positive correlation observed between IL-4 and IL-2 as well IL-4 and IL-17 levels. In contrast, worse survival rate was associated with IL-2, IL-4 and IL-10 levels imbalance. In addition, increased sHLA-G levels at diagnosis were associated with increased leukocyte count, a well-known factor for poor prognosis. In conclusion, cytokines and sHLA-G play an essential role in marrow T-ALL microenvironment during chemotherapy, especially the immunosuppressive cytokine IL-10 which can be used as biomarker of disease outcome, being also a potential target for novel T-ALL treatments. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
Affilliation | IMIP Hospital. Pediatric Oncology Service. Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil. | pt_BR |
Affilliation | IMIP Hospital. Pediatric Oncology Service. Recife, PE, Brazil. | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Medicine. Division of Clinical Immunology. Ribeirão Preto, SP, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil / IMIP Hospital. Pediatric Oncology Service. Recife, PE, Brazil. | pt_BR |
Subject | T-cell Acute Lymphoblastic Leukemia | |
Subject | Bone marrow | |
Subject | IL-10 | |
Subject | IFN-γ | |
Subject | Prognosis | |
DeCS | Adolescente | pt_BR |
DeCS | Biomarcadores | pt_BR |
DeCS | Medula Óssea | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Citocinas | pt_BR |
DeCS | Fêmea | pt_BR |
DeCS | Antígenos HLA-G | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Interferon-gamma | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Estimativa de Kaplan-Meier | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Leucemia | pt_BR |
DeCS | Imunologia | pt_BR |
DeCS | Linfoma Linfoblástico Precursor de Células T | pt_BR |
DeCS | Prognóstico | pt_BR |
DeCS | Solubilidade | pt_BR |
DeCS | Taxa de sobrevivência | pt_BR |
DeCS | Microambiente Tumoral | pt_BR |
Embargo date | 2030-12-31 | |