Author | Firmino, Alisson de Aquino | |
Author | Martins, Adenilda Lima Lopes | |
Author | Gois, Luana Leandro | |
Author | Paixão, Taiane Silva | |
Author | Batista, Everton da Silva | |
Author | Castro Filho, Bernardo Galvão | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2019-05-13T16:50:08Z | |
Available date | 2019-05-13T16:50:08Z | |
Document date | 2019 | |
Citation | FIRMINO, Alisson de Aquino et al. Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women. Brazilian Journal of Infectious Diseases, v. 23, n. 1, p. 27-33, 2019. | pt_BR |
ISSN | 1413-8670 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33047 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia (BOL0575/2015). This study wasfinanced in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | Citocinas Inflamatórias | pt_BR |
Subject in Portuguese | Carga Proviral | pt_BR |
Subject in Portuguese | Citopatologia cervicovaginal | pt_BR |
Title | Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bjid.2019.02.001 | |
Abstract | Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendi-mento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected womenreported any HTLV-1-associated diseases. All volunteers underwent gynecological exam-ination to collect cervicovaginal fluid. Cytokine quantification was performed using theCytometric Bead Array (CBA) Human Th1/Th2/Th17 kit. Light microscopy was used to eval-uate cervicovaginal cytopathology. In addition, proviral load in cervicovaginal fluid andperipheral blood was measured by real-time quantitative polymerase chain reaction.Results: 112 women (63 HTLV-1-infected and 49 uninfected) were evaluated. No differenceswere found with respect to cytopathological cervicovaginal findings between the groups.IL-2, TNF, IL-4, IL-10, and IL-17 levels were significantly higher in cervicovaginal fluid of theHTLV-1-infected women than in uninfected women (p < 0.05). Conversely, IFN- was foundto be lower in the HTLV-1-infected women (p < 0.001) compared to uninfected individuals.Cervicovaginal proviral load was detectable in 53% of the HTLV-1-infected women and wasfound to be consistently lower than the proviral load in peripheral blood.Conclusions: HTLV-1 infection induces immune activation in cervicovaginal environment. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Inflammatory cytokines | pt_BR |
Subject | Proviral load | pt_BR |
Subject | Cervicovaginal cytopathology | pt_BR |