Author | Faria, Elaine Speziali de | |
Author | Menezes, Juscilene da Silva | |
Author | Santiago, Andrezza | |
Author | Vaz, Nelson Monteiro | |
Access date | 2019-04-23T18:42:18Z | |
Available date | 2019-04-23T18:42:18Z | |
Document date | 2018 | |
Citation | FARIA, Elaine Speziali de et al. Lifelong Maintenance of Oral Tolerance and Immunity Profiles in Mice Depends on Early Exposure to Antigen. Scandinavian journal of immunology, v. 87, n. 2, p. 73-79, 2018. | pt_BR |
ISSN | 0300-9475 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32688 | |
Language | eng | pt_BR |
Publisher | Blackwell Scientific Publications | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | tolerancia oral | pt_BR |
Subject in Portuguese | antigenos | pt_BR |
Title | Lifelong Maintenance of Oral Tolerance and Immunity Profiles in Mice Depends on Early Exposure to Antigen | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/sji.12635 | |
Abstract | Oral tolerance is defined as a state of systemic hyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction; some of them related to antigen, and some related to the animal. The age of the animal is one of the most important factors that affect oral tolerance as ageing brings many alterations in immune responses. Herein, we demonstrated that both the oral tolerance and pattern of immune reactivity triggered in early life were kept up to 15 months regarding the magnitude of antibody production, cell proliferation and cytokine profile when compared to immune responses induced in old mice. Therefore, our results corroborate with a promising proposal for prevaccination during childhood and young age, and a booster in older age, to make sure that the primary immunization in early life is not lost in aged individual. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil / Hologic. Bedford, MA, USA. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
Subject | Oral tolerance | pt_BR |
Subject | antigen | pt_BR |
Embargo date | 2100-01-01 | |