Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/32668
Type
ArticleCopyright
Restricted access
Embargo date
2050-01-01
Collections
Metadata
Show full item record
TWO SIDES OF A COIN: GG GENOTYPE OF C7 PROVIDES PROTECTION AGAINST FIBROSIS SEVERITY WHILE SHOWING A HIGHER RISK FOR HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS C
Envelhecido
Alelos
Carcinoma Hepatocelular / genética
Complemento C7 / genética
Complexo de ataque à membrana do complemento / metabolismo
Fêmea
Fibrose
Predisposição Genética para Doença
Genótipo
Hepacivirus / fisiologia
Hepatite C, Crônica / genética
Humanos
Fígado / patologia
Fígado / fisiologia
Neoplasias Hepáticas / genética
Masculino
Meia idade
Polimorfismo de Nucleotídeo Único
Author
Affilliation
University of Pernambuco. Institute of Biological Sciences. Recife, PE, Brazil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
University of Pernambuco. Institute of Biological Sciences. Recife, PE, Brazil.
Federal University of São Francisco Valley. Recife, PE, Brazil.
Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil / University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil.
Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil / University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil.
University of Pernambuco. Institute of Biological Sciences. Recife, PE, Brazil.
University of Pernambuco. Institute of Biological Sciences. Recife, PE, Brazil.
Federal University of São Francisco Valley. Recife, PE, Brazil.
Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil / University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil.
Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil / University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Institute of Liver and Transplantation of Pernambuco. Recife, PE, Brazil.
University of Pernambuco. Institute of Biological Sciences. Recife, PE, Brazil.
Abstract
The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination. Patients were classified by their METAVIR score as F1 (n = 100), F2 (n = 83), F3 (n = 101) or F4 (n = 66); 106 patients were diagnosed with HCC. Patients carrying the G/G genotype of C7 had a lower chance of developing severe fibrosis in the recessive model (p = 0.042; OR: 0.65 95% CI 0.41-1.02). However, the G/G genotype frequency was higher in patients with HCC (P = 0.01; OR: 2.07 95% CI 1.20-3.53) and in those with larger tumors (p = 0.04). The G/G C7 genotype seems to be a protective factor against advanced fibrosis; however, it was associated with a higher risk of HCC and the occurrence of larger hepatic nodules, suggesting the involvement of C7 in the physiopathogenesis of HCC and fibrosis in patients with hepatitis C virus (HCV).
DeCS
AdultoEnvelhecido
Alelos
Carcinoma Hepatocelular / genética
Complemento C7 / genética
Complexo de ataque à membrana do complemento / metabolismo
Fêmea
Fibrose
Predisposição Genética para Doença
Genótipo
Hepacivirus / fisiologia
Hepatite C, Crônica / genética
Humanos
Fígado / patologia
Fígado / fisiologia
Neoplasias Hepáticas / genética
Masculino
Meia idade
Polimorfismo de Nucleotídeo Único
Share