Author | Barros, Fernando de | |
Author | Setúbal, Sérgio | |
Author | Martinho, José Manoel | |
Author | Leite, Nathalie Carvalho | |
Author | Guaraná, Thais | |
Author | Monteiro, Ana Beatriz Soares | |
Author | Villela-Nogueira, Cristiane A. | |
Access date | 2019-04-18T14:11:32Z | |
Available date | 2019-04-18T14:11:32Z | |
Document date | 2016 | |
Citation | BARROS, Fernando de et al. The correlation between obesity-related diseases and non-alcoholic fatty liver disease in women in the pre-operative evaluation for bariatric surgery assessed by transient hepatic elastography. Obesity Surgery, v. 26, p. 2089-2097, 2016. | pt_BR |
ISSN | 0960-8923 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32593 | |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Title | The correlation between obesity-related diseases and non-alcoholic fatty liver disease in women in the pre-operative evaluation for bariatric surgery assessed by transient hepatic elastography | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s11695-016-2054-y | |
Abstract | Background: Non-alcoholic fatty liver disease (NAFLD) is a common, severe disease in obese patients. However, NAFLD is usually underestimated by ultrasonography. Liver biopsy is not routinely done in bariatric surgery or during the follow-up. This study therefore examined the correlation between metabolic syndrome and NAFLD in morbidly obese patients based on an assessment using transient hepatic elastography (THE). Material and Methods: This study involved 50 female patients in the pre-operative phase for bariatric surgery. Before surgery, we collected clinical, laboratory, and anthropometric variables. THE measurements were obtained using a FibroScan® device (Echosens, Paris, France), and steatosis was quantified using Controlled Attenuation Parameter software (CAP). Statistical analyses were done using linear correlation and the Kruskal-Wallis test. Results: The mean of THE and CAP values were 7.56± 4.78 kPa and 279.94 ± 45.69 dB/m, respectively, and there was a significant linear correlation between the two measurements (r = 0.651; p< 0.001). The numbers of metabolic syndrome parameters did not influence the THE (p = 0.436) or CAP (p = 0.422) values. HbA1c and HOMA-IR showed a strong linear correlation with CAP (r= 0.643, p = 0.013 and r= 0.668, p = 0.009, respectively) and a tendency to some linear correlation with THE (r = 0.500, p = 0.05 and r = 0.500, p = 0.002, respectively). Conclusion: Morbidly obese women submitted to FibroScan® presented a high prevalence of severe steatosis and advanced fibrosis in our sample. Insulin resistance parameters were correlated with steatosis, but less with fibrosis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Andaraí Federal Hospital. Rio de Janeiro, RJ, Brazil / Fluminense Federal University. Postgraduate Program. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Fluminense Federal University. Postgraduate Program in Medical Sciences. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Fluminense Federal University. Department of General Surgery. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Rio de Janeiro Federal University. Internal Medicine Division. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Fluminense Federal University. Department of Gastroenterology. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Fluminense Federal University. Department of Statistics. Niterói, RJ, Brazil. | pt_BR |
Affilliation | Rio de Janeiro Federal University. School of Medicine. Rio de Janeiro, RJ, Brazil. | pt_BR |
Subject | Bariatric surgery | pt_BR |
Subject | Fatty liver | pt_BR |
Subject | Metabolic syndrome X | pt_BR |
Subject | Morbid obesity | pt_BR |
Subject | Non-invasive test | pt_BR |
Subject | Transient elastography | pt_BR |
e-ISSN | 1708-0428 | |
Embargo date | 2020-04-15 | |