Author | Castro, D. P. | |
Author | Figueiredo, M. B. | |
Author | Ribeiro, I. M. | |
Author | Tomassini, T. C. B. | |
Author | Azambuja, P. | |
Author | Garcia, E. S. | |
Access date | 2019-04-16T11:27:45Z | |
Available date | 2019-04-16T11:27:45Z | |
Document date | 2008 | |
Citation | CASTRO, D. P. et al. Immune depression in Rhodnius prolixus by seco-steroids, physalins. Journal of Insect Physiology, v. 54, p. 555-562, 2008. | pt_BR |
ISSN | 0022-1910 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32504 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Rhodnius prolixus | pt_BR |
Subject in Portuguese | Physalis angulata L | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Title | Immune depression in Rhodnius prolixus by seco-steroids, physalins | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jinsphys.2007.12.004 | |
Abstract | A comparative study of the effects of physalins, seco-steroidal substances of Physalis angulata (Solanaceae), on the immune reactions of R. prolixus was carried out. Ecdysis and mortality were not affected by treatment with physalins B, D, F or G (1-10 microg/ml of blood meal). R. prolixus larvae fed with blood containing physalins and inoculated with 1 microl of Enterobacter cloacae beta12 (5 x 10(3)/insect) exhibited mortality rates three times higher than controls. The insects treated with physalin B, and F (1 microg/ml) and inoculated with E. cloacae beta12 showed significant differences on lysozyme activity in the hemolymph compared to untreated insects. Furthermore, physalin D (1 microg/ml) significantly reduced the antibacterial activity. Concerning cellular immune reactions, all insects treated with physalins (1 microg/ml), exhibited drastic reductions in the quantity of yeast cell-hemocyte binding and subsequent internalization. Insects inoculated with bacteria and treated with physalins B, F and G showed reductions of microaggregate formation but physalin D did not. Physalins B and F also reduced total hemocyte count in the hemolymph. These results suggest that, in different ways, probably due to their different chemical structures, physalin B, D, F and G are immunomodulatory substances for the bloodsucking insect, R. prolixus. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Rio de janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Rio de janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Seco-steroids | pt_BR |
Subject | Rhodnius prolixus | pt_BR |
Subject | Physalis angulata L | pt_BR |
Subject | Physalin | pt_BR |
Subject | Immune response | pt_BR |
Embargo date | 2022-01-01 | |