Author | Amorim, Camila Farias | |
Author | Carvalho, Natália Barbosa | |
Author | Abraão Neto, José | |
Author | Santos, Silvane Maria Braga | |
Author | Grassi, Maria Fernanda Rios | |
Author | Carvalho, Lucas Pedreira de | |
Author | Carvalho, Edgar Marcelino de | |
Access date | 2019-04-15T18:37:09Z | |
Available date | 2019-04-15T18:37:09Z | |
Document date | 2019 | |
Citation | AMOARIM, Camila Farias et al. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research, p. 1-10, 2019. | pt_BR |
ISSN | 2314-8861 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32501 | |
Sponsorship | Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais, which is financed by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) from Ministério da Ciência, Tecnologia, Inovações e Comunicações (grant number 465229/2014-0). | pt_BR |
Language | eng | pt_BR |
Publisher | Hindwai | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | Vírus Linfotrópico T Humano 1 | pt_BR |
Subject in Portuguese | Células NK | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Title | The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2019/6574828 | |
Abstract | The cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1). As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes. NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection. The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP. The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot. Phenotypic characterization of NK cells was performed by flow cytometry. The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients. The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients. HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC. These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clinicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil. | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Human T-lymphotropic virus 1 | pt_BR |
Subject | Killer Cells, Natural | pt_BR |
Subject | Infection | pt_BR |
Subject | Humans | pt_BR |