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2050-01-01
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RISK ANALYSIS AND SEROPREVALENCE OF HEV IN PEOPLE LIVING WITH HIV/AIDS IN BRAZIL
Adulto
Brasil / epidemiologia
Coinfecção / epidemiologia
Fêmea
Anticorpos Contra Hepatite / sangue
Hepatite E / sangue
Hepatite E / epidemiologia
Vírus da hepatite E / imunologia
Humanos
Masculino
Meia idade
Prevalência
Avaliação de risco
Fatores de risco
Estudos soroepidemiológicos
Abastecimento de água
Author
Affilliation
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Foundation Oswaldo Cruz. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil.
Foundation Oswaldo Cruz. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Santa Maria. Department of Preventive Veterinary Medicine. Virology Section. Santa Maria, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil / Federal University of Pernambuco. Center of Biosciences. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Foundation Oswaldo Cruz. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil.
Foundation Oswaldo Cruz. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Santa Maria. Department of Preventive Veterinary Medicine. Virology Section. Santa Maria, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Virology Section. Recife, PE, Brazil / Federal University of Pernambuco. Center of Biosciences. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Abstract
Acute Hepatitis E virus (HEV) infection in people living with HIV/AIDS (PLHA) can lead to fulminant hepatic failure, cirrhosis and death. The prevalence of anti-HEV antibodies within this group varies according to the geographical area. However, in South America, studies concerning the detection of HEV in PLHA are rare. Here, we investigated the presence of HEV by serological and molecular detection and evaluated the risk factors associated with infection in PLHA in Pernambuco state, Brazilian Northeast. Serological and molecular detection of HEV was performed in 366 samples of PLHA by ELISA for anti-HEV IgG and RT-PCR, respectively. Anti-HEV IgG prevalence was 4.1% (15/366) and no HEV RNA was detected. Concerning the risk factors, we evaluated, in multivariable analysis, age, years of school, sexual orientation, oral-anal sex, use of injectable drugs and piped water. Among them, only piped water availability could be associated with the HEV infection in PLHA (OR: 0.08; CI 95%: 0.01-0.66; p = 0.0182). This study showed for the first time the association of piped water as protection factor for HEV infection in PLHA. Finally, this is also the first report of HEV seroprevalence in PLHA in the Northeast Brazil.
DeCS
Síndrome de Imunodeficiência Adquirida / epidemiologiaAdulto
Brasil / epidemiologia
Coinfecção / epidemiologia
Fêmea
Anticorpos Contra Hepatite / sangue
Hepatite E / sangue
Hepatite E / epidemiologia
Vírus da hepatite E / imunologia
Humanos
Masculino
Meia idade
Prevalência
Avaliação de risco
Fatores de risco
Estudos soroepidemiológicos
Abastecimento de água
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