Author | Reis, Dijovani Batista dos | |
Author | Souza, Thalita Cristina Alves | |
Author | Lourenço, Maria Cristina S. | |
Author | Almeida, Mauro Vieira de | |
Author | Barbosa, Adriano | |
Author | Eger, Iriane | |
Author | Saraiva, Mauricio Frota | |
Access date | 2019-04-05T15:01:08Z | |
Available date | 2019-04-05T15:01:08Z | |
Document date | 2016 | |
Citation | REIS, Dijovani Batista dos et al. Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids. Biomedicine and Pharmacotherapy, v. 84, p. 1739-1747, 2016. | pt_BR |
ISSN | 0753-3322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32397 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.biopha.2016.10.112 | |
Abstract | We report the synthesis of a series of diaminated terpenoids containing, as side-chain of the diamine core, the "head-to-tail" prenyl derivatives, with amino amino spacers of variable length. In vitro biological activity of these compounds was evaluated against Mycobacterium tuberculosis and Leishmania amazonensis, and the structure-activity relationships are discussed. Different biological results were observed depending on the terpenic side-chain length. The best results were obtained for trans,trans-farnesol derivatives. Moreover, these results demonstrated that the stereochemistry of the double bond could play an important role in determining antitubercular and antileishmanial activities of these compounds. | pt_BR |
Affilliation | Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas Clínicas Evandro Chagas. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Ponta Grossa. Departamento de Biologia Geral. Ponta Grossa, PR, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Ponta Grossa. Departamento de Biologia Geral. Ponta Grossa, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal de Itajubá. Instituto de Física e Química. Itajubá, MG, Brasil. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Diamine | pt_BR |
Subject | Terpenoid | pt_BR |
Embargo date | 2020-04-05 | |