Author | Matos, Denise Cristina Souza | |
Author | Marcovistz, Rugimar | |
Author | Silva, Andréa Marques Vieira da | |
Author | Quintilio, Wagner | |
Author | Georgini, Ricardo Amaral | |
Access date | 2019-03-08T17:18:28Z | |
Available date | 2019-03-08T17:18:28Z | |
Document date | 2012 | |
Citation | MATOS, Denise Cristina Souza et al. Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine. Braz. J. Microbiol., São Paulo , v. 43, n. 2, p. 429-431, 2012. | pt_BR |
ISSN | 1678-4405 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32005 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | DTP vaccine | pt_BR |
Subject in Portuguese | Pertussis whole cell | pt_BR |
Subject in Portuguese | Enzyme-linked immunosorbent assay | pt_BR |
Subject in Portuguese | Intracerebral mouse protection test | pt_BR |
Title | Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S1517-83822012000200001 | |
Abstract | The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Butantan. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Instituto Butantan. São Paulo, SP, Brasil. | pt_BR |