Author
Affilliation
Abstract
Objectives: Antimicrobial resistance (AMR) is a priority for surveillance in bacterial infections. For leprosy,
AMR has not been assessed because Mycobacterium leprae does not grow in vitro. We aim to obtain AMR
data using molecular detection of resistance genes and to conduct a prospective open survey of resistance
to antileprosy drugs in countries where leprosy is endemic through a WHO surveillance network.
Methods: From 2009 to 2015, multi-bacillary leprosy cases at sentinel sites of 19 countries were studied
for resistance to rifampicin, dapsone and ofloxacin by PCR sequencing of the drug-resistancedetermining
regions of the genes rpoB, folP1 and gyrA.
Publisher
Elsevier
Citation
CAMBAU, E. et al. Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15. Clinical Microbiology and Infection, v. 24, p. 1305-1310, Mar. 2018.
DOI
10.1016/j.cmi.2018.02.022
ISSN
1198-743X
Notes
AUTHORS - E. Cambau 1, *, P. Saunderson 2, M. Matsuoka 3, S.T. Cole 4, 5, M. Kai 3, P. Suffys 6, P.S. Rosa 7,
D. Williams 8, U.D. Gupta 9, M. Lavania 10, N. Cardona-Castro 11, Y. Miyamoto 3, D. Hagge 12,
A. Srikantam 13, W. Hongseng 14, A. Indropo 15, V. Vissa 16, R.C. Johnson 5, B. Cauchoix 5,
V.K. Pannikar 17, E.A.W.D. Cooreman 17, V.R.R. Pemmaraju 17, L. Gillini 17 on behalf
of the WHO surveillance network of antimicrobial resistance in leprosyy AFFILIATIONS - 1) Universit e Paris Diderot, UMR 1137 IAME Inserm, APHP-Lariboisi ere, APHP-Pitie-Salp^etri ere, Centre de R ef erence des Mycobact eries et de la r esistance des
mycobact eries aux antituberculeux, Paris, France
2) American Leprosy Missions, Greenville, SC, USA
3) Leprosy Research Centre, National Institute of Infectious Diseases, Tokyo, Japan
4) Global Health Institute, Ecole Polytechnique F ed erale de Lausanne, Switzerland
5) Fondation Raoul Follereau, Paris, France
6) Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
7) Instituto Lauro de Souza Lima, Sao Paulo, Brazil
8) National Hansen's Disease Programs, Baton Rouge, USA
9) National JALMA Institute of Leprosy & Other Mycobacterial Diseases, Agra, India
10) Stanley Browne Laboratory, TLM Community Hospital, Delhi, India
11) Institute Colombiano de Medicina Tropical, Sabaneta, Antioquia, Colombia
12) Mycobacterial Research Laboratories, Anandaban Hospital, Kathmandu, Nepal
13) Lepra Blue Peter Public Health and Research Centre, Hyderabad, India
14) Institute of Dermatology, Chinese Academy of Medical Sciences, National Center for STD and Leprosy Control, China CDC, China
15) Airlangga University, Surabaya, Indonesia
16) Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
17) Global Leprosy Programme, WHO Regional Office for South-East Asia, New Delhi, India.
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