Author | Tsui, Irena | |
Author | Moreira, Maria Elisabeth Lopes | |
Author | Rossetto, Julia D. | |
Author | Vasconcelos, Zilton | |
Author | Gaw, Stephanie L. | |
Author | Neves, Luiza M. | |
Author | Zin, Olivia A. | |
Author | Haefeli, Lorena | |
Author | Silveira Filho, Joel Carlos Barros | |
Author | Gomes Jr, Saint Clair | |
Author | Adachi, Kristina | |
Author | Pone, Marcos Vinicius da Silva | |
Author | Pone, Sheila Moura | |
Author | Pereira Jr, Jose Paulo | |
Author | Belfort, Rubens | |
Author | Arumugaswami, Vaithilingaraja | |
Author | Brasil, Patricia | |
Author | Nielsen-Saines, Karin | |
Author | Zin, Andrea A. | |
Access date | 2019-02-14T11:23:30Z | |
Available date | 2019-02-14T11:23:30Z | |
Document date | 2018 | |
Citation | TSUI, Irena et al. Eye findings in infants with suspected or confirmed antenatal Zika virus exposure. Pediatrics, v. 142, n. 4, p. 1-10, Oct. 2018. | pt_BR |
ISSN | 0031-4005 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31631 | |
Language | eng | pt_BR |
Publisher | American Academy of Pediatrics | pt_BR |
Rights | restricted access | pt_BR |
Title | Eye findings in infants with suspected or confirmed antenatal Zika virus exposure | pt_BR |
Type | Article | pt_BR |
DOI | 10.1542/peds.2018-1104 | |
Abstract | Objectives: To characterize ophthalmic manifestations of confirmed or suspected antenatal Zika virus (ZIKV) exposure. Methods: Infants with antenatal ZIKV exposure were referred for evaluation during the 2015–2016 Rio de Janeiro outbreak. Mothers with symptomatic ZIKV infection during pregnancy and/or infants with microcephaly or other findings that were suggestive of suspected antenatal exposure were tested with reverse transcriptase polymerase chain reaction (RT-PCR). Complete eye examinations were performed by pediatric ophthalmologists between January 2016 and February 2017. The main outcome measure was eye abnormalities in RT-PCR–positive and suspected (ie, not tested or RT-PCR–negative) antenatal ZIKV cases. Results: Of 224 infants, 189 had RT-PCR testing performed. Of 189 patients, 156 had positive RT-PCR results in their blood, urine, and/or placenta. Of 224 infants, 90 had central nervous system (CNS) abnormalities, including microcephaly (62 infants). Eye abnormalities were present in 57 of 224 (25.4%) infants. Optic nerve (44 of 57; 77.2%) and retina abnormalities (37 of 57; 64.9%) were the most common. The group with suspected ZIKV infection (68 infants) had proportionally more eye (36.8% vs 20.5%; P = .022) and CNS abnormalities (68.3% vs 28.1%; P = .008), likely because of referral patterns. Eye abnormalities consistent
with ZIKV infection were clinically comparable in both RT-PCR–positive and unconfirmed groups, including 4 RT-PCR–positive infants of 5 without any CNS abnormalities. Conclusions: Similar eye manifestations were identified regardless of laboratory confirmation. Well-appearing infants were also found to have eye abnormalities. Therefore, all infants born after ZIKV outbreaks should be universally screened for eye abnormalities. | pt_BR |
Affilliation | University of California. Department of Opthalmology. Retina Division. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of California. Department of Obstetrics, Gynecology, and Reproductive Services. Division of Maternal-Fetal Medicine. San Francisco, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil / Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Grande Rio. Departamento de Oftalmologia. Duque de Caxias, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of California. Department of Pediatrics. Division of Infectious Disease. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Oftalmologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | University of California. Department of Opthalmology. Retina Division. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of California. Department of Pediatrics. Division of Infectious Disease. Los Angeles, CA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Zika virus | pt_BR |
Subject | Antenatal Zika virus exposure | pt_BR |
Subject | Ophthalmic manifestations | pt_BR |
e-ISSN | 1098-4275 | |
Embargo date | 2030-12-31 | |