Author | Conceição, Emilyn Costa | |
Author | Guimarães, Arthur Emil dos Santos | |
Author | Lopes, Maria Luíza | |
Author | Furlaneto, Ismari Perini | |
Author | Rodrigues, Yan Corrêa | |
Author | Conceição, Marília Lima da | |
Author | Barros, Wandyra Araújo | |
Author | Cardoso, Ninarosa Calzavara | |
Author | Sharma, Abhinav | |
Author | Lima, Luana Nepomuceno Gondim Costa | |
Author | Gomes, Harrison Magdinier | |
Author | Duarte, Rafael Silva | |
Author | Frota, Cristiane | |
Author | Rutaihwa, Liliana K. | |
Author | Gagneux, Sebastien | |
Author | Suffys, Philip Noel | |
Author | Lima, Karla Valéria Batista | |
Access date | 2019-02-06T13:54:46Z | |
Available date | 2019-02-06T13:54:46Z | |
Document date | 2018 | |
Citation | CONCEIÇÃO, Emilyn Costa; et al. Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil. Tuberculosis, v.113, p.125-129, 2018. | pt_BR |
ISSN | 1472-9792 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31455 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Epidemiologia molecular | pt_BR |
Subject in Portuguese | Contatos domésticos | pt_BR |
Subject in Portuguese | Genotipagem | pt_BR |
Subject in Portuguese | Resistência a medicamentos | pt_BR |
Subject in Portuguese | Sequenciamento do genoma inteiro | pt_BR |
Title | Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil | pt_BR |
Type | Article | |
DOI | 10.1016/j.tube.2018.09.011 | |
Abstract | Tuberculosis (TB) is an infectious disease with a higher risk for infection and disease among household contacts (HHC). Here, we report a molecular epidemiology-based approach to study disease transmission and the genetic characteristics of Mycobacterium tuberculosis (Mtb) strains among HHC in the city of Belem, the capital of the state of Para in north Brazil. The study included 63 TB patients belonging to 26 HHC groups (HHC1 to HHC26). Spoligotyping and 24-loci Mycobacterial Interspersed Repetitive Unit - Variable Number of Tandem Repeat (MIRU-VNTR) revealed indistinguishable bacterial genotypes among 26 patients in 14 (53.8%) HHC groups. Drug susceptibility testing (DST) revealed that 45 (71.4%) of the Mtb isolates were multidrug resistant. The major cluster composed of isolates from five HHCs and on three of these, whole genome sequencing (WGS) was performed confirming their high genetic similarity. These results pinpoint the need for improved vigilance for TB control in households in the city of Belém. When comparing WGS versus phenotypic resistance detection methods as DST and Minimum Inhibitory Concentration (MIC) our data suggest that depending on the colonies selection, results may present variation. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro.Instituto de Microbiologia Paulo de Goés.Rio de Janeiro, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil. | pt_BR |
Affilliation | Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil. | pt_BR |
Affilliation | Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil. | pt_BR |
Affilliation | Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil. | pt_BR |
Affilliation | University of Delhi. Delhi College of Engineering. New Delhi, India . | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil.. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada as Micobactérias, Rio de Janeiro, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro.Instituto de Microbiologia Paulo de Goés.Rio de Janeiro, Brasil. | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil. | pt_BR |
Affilliation | Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland. | pt_BR |
Affilliation | Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada as Micobactérias, Rio de Janeiro, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Household contacts | pt_BR |
Subject | Molecular epidemiology | pt_BR |
Subject | Genotyping | pt_BR |
Subject | Multi-drug resistance | pt_BR |
Subject | Whole genome sequencing | pt_BR |
Embargo date | 2020-01-01 | |