Author | Canela, Luciana Nascimento Pinto | |
Author | Barbosa, Maria Clara de Magalhães | |
Author | Raymundo, Carlos Eduardo | |
Author | Carney, Sharon | |
Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
Author | Barbosa, Arnaldo Prata | |
Author | Cunha, Antonio José Ledo Alves da | |
Access date | 2019-02-05T14:17:35Z | |
Available date | 2019-02-05T14:17:35Z | |
Document date | 2018 | |
Citation | CANELA, Luciana Nascimento Pinto et al. Viral detection profile in children with severe acute respiratory infection. The Brazilian Journal of Infectious Diseases, v. 22, n. 5, p. 402-411, Oct. 2018. | pt_BR |
ISSN | 1413-8670 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31425 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Infectologia | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Criança | pt_BR |
Subject in Portuguese | Co-detecção | pt_BR |
Subject in Portuguese | Unidade de terapia intensiva pediátrica | pt_BR |
Subject in Portuguese | Infecção respiratória aguda grave | pt_BR |
Subject in Portuguese | Influenza Pandemia H1N1 | pt_BR |
Title | Viral detection profile in children with severe acute respiratory infection | pt_BR |
Type | Article | |
DOI | 10.1016/j.bjid.2018.09.001 | |
Abstract | Objectives: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic. Method: Longitudinal observational retrospective study, with patients aged 0–18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009. The results of respiratory samples which were sent to the Laboratory of Fiocruz/RJ
and clinical data extracted from specific forms were analyzed. Results: Of 71 samples, 38% tested positive for H1N1 virus. Of the 63 samples tested for other viruses, 58 were positive: influenza H1N1 (43.1% of positive samples), rhinovirus/enterovirus (41.4%), respiratory syncytial vírus (12.1%), human metapneumovirus (12.1%), adenovirus (6.9%), and bocavirus (3.5%). Viral codetection occured in 22.4% of the cases. H1N1-positive patients were of a higher median age, had higher frequency of fever, cough and tachypnea, and decreased leukometry when compared to H1N1-negative patients. There was no difference in relation to severity outcomes (number of organic dysfunctions, use of mechanical ventilation or amines, hospital/PICU length of stay or death). Comparing the groups
with mono-detection and co-dection of any virus, no difference was found regarding the association with any clinical variable. Conclusions: Other viruses can be implicated in SARI in children. The role of viral codetection
has not yet been completely elucidated. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Pandemic H1N1 Influenza | pt_BR |
Subject | Co-detection | pt_BR |
Subject | Pediatric intensive care unit | pt_BR |
Subject | Severe acute respiratory infection | pt_BR |
Subject | Child | pt_BR |
e-ISSN | 1678-4391 | |
Embargo date | 2030-01-01 | |