Author | Varandas, Cinthya Maria Neves | |
Author | Silva, José Lucas Sena da | |
Author | Primo, Janeusa Rita Leite | |
Author | Oliveira, Maria de Fátima S. P. de | |
Author | Carvalho, Otávio Moreno | |
Author | Vallve, Maria Lourdes Farre | |
Author | Bittencourt, Achilea Candida Lisboa | |
Access date | 2019-02-05T13:44:17Z | |
Available date | 2019-02-05T13:44:17Z | |
Document date | 2018 | |
Citation | VARANDAS, C. M. N. et al. Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. Clinical Infectious Diseases, v. 67, n. 9, p. 1427–1433, 2018. | pt_BR |
ISSN | 1058-4838 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31421 | |
Sponsorship | Fundação de Amparo à
Pesquisa do Estado da Bahia (FAPESB) [grant number RED0028/2012 to
L. F.] and Conselho Nacional de Desenvolvimento Científico e Tecnológico
– CNPq [grant number 409985/2016-3 to A. L. B.]. | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | HAM / TSP | pt_BR |
Subject in Portuguese | Dermatite infecciosa | pt_BR |
Subject in Portuguese | Agrupamento de HTLV-1 | pt_BR |
Subject in Portuguese | Transmissão vertical | pt_BR |
Title | Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/cid/ciy289 | |
Abstract | Human T-cell lymphotropic virus type-1 (HTLV-1) may cause severe diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). The clinical characteristics and progression of 25 early onset HAM/TSP associated or not to IDH were described. Methods. Following-up 37 IDH patients with neurological examinations, 54% developed HAM/TSP. To these cases were added
5 cases of juvenile HAM/TSP. The patients were HTLV-1+ and were submitted to dermatological and neurological examinations.
Diagnosis of HAM/TSP was performed according to Osame et al (1990) and Castro-Costa et al (2006) criteria.
Results. Twenty-one patients were classified as definite HAM/TSP by both criteria, 3 as probable HAM/TSP by Osame et al, and
another as probable HAM/TSP according to Castro-Costa et al Median age at onset of neurological manifestations was 9 years for
the IDH/HAM/TSP group and 16 years for the HAM/TSP group (P = .045). In 12 patients, the onset of neurological manifestations
occurred when they were less than 10 years of age. In the group IDH/HAM/TSP, the neurological symptoms always begun during the
period of activity of IDH. The progression of HAM/TSP evaluated in 17 cases was heterogeneous, and 3 had rapid progressive course.
Conclusions. The juvenile HAM/TSP may occur very early and also presents marked female predominance. Progression of IDH
to HAM/TSP before 19 years of age is frequent (54%). Rapid progressive form may also occur in early HAM/TSP. As juvenile IDH
and HAM/TSP are due to vertical transmission through breastfeeding, it is very important to avoid this pathway of infection. | pt_BR |
Affilliation | Hospital Santo Antonio das Obras Sociais Irmã Dulce. Pediatric Neurology Unit. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital Santo Antonio das Obras Sociais Irmã Dulce. Pediatric Neurology Unit. Salvador, BA, Brasil / Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Internal Medicine. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Internal Medicine. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Internal Medicine. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Catalan Institute of Oncology. Bellvitge Institute for Biomedical Research. L’Hospitalet del Llobregat. Against Cancer Therapeutic Resistance. Catalonia, Spain. | pt_BR |
Affilliation | Federal University of Bahia. Professor Edgard Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil. | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | HAM/TSP | pt_BR |
Subject | Infective dermatitis | pt_BR |
Subject | HTLV-1 clustering | pt_BR |
Subject | Vertical transmission | pt_BR |