Author | Righy, Cássia | |
Author | Turon, Ricardo | |
Author | Freitas, Gabriel de | |
Author | Japiassú, André Miguel | |
Author | Faria Neto, Hugo C. Castro | |
Author | Bozza, Marcelo | |
Author | Oliveira, Marcus F. | |
Author | Bozza, Fernando A. | |
Access date | 2019-01-31T15:13:19Z | |
Available date | 2019-01-31T15:13:19Z | |
Document date | 2018 | |
Citation | RIGHY, Cássia et al. Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke. Rev. Bras. Ter. Intensiva, p. 1-7, 2018. | pt_BR |
ISSN | 0103-507X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31358 | |
Language | eng | pt_BR |
Publisher | Associação de Medicina Intensiva Brasileira | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Heme | pt_BR |
Subject in Portuguese | Ferro | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Subject in Portuguese | Sistema nervoso central | pt_BR |
Title | Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke | pt_BR |
Alternative title | Subprodutos do metabolismo da hemoglobina se associam com resposta inflamatória em pacientes com acidente vascular cerebral hemorrágico | pt_BR |
Type | Article | pt_BR |
DOI | 10.5935/0103-507X.20180003 | |
Abstract | Objective: To evaluate the relationships of brain iron and heme
with the inflammatory response of the systemic and central nervous systems and to investigate the role of defensive systems against the toxicity of iron and heme in the central nervous system. Methods: We assessed a prospective cohort of patients presenting with intracerebral and subarachnoid hemorrhage. We assayed plasma and cerebrospinal fluid samples for the presence of iron, heme, hemopexin, haptoglobin, enolase, S100-β and cytokines for the first three days following hemorrhagic stroke. We also analyzed the dynamic changes in these
components within both fluids and their relationship with early mortality rates. Results: Hemopexin and haptoglobin concentrations were nearly
negligible in the brain after intracerebral and subarachnoid hemorrhage.
Cerebrospinal fluid iron and heme concentrations correlated with a proinflammatory response in the central nervous system, and plasmatic and cerebrospinal fluid inflammatory profiles on the third day after hemorrhagic stroke were related to early mortality rates. Interleukin 4 levels within the cerebrospinal fluid during the first 24 hours after hemorrhagic stroke were found to be higher in survivors than in non-survivors. Conclusion: Iron and heme are associated with a pro-inflammatory response in the central nervous system following hemorrhagic stroke, and protections against hemoglobin and heme are lacking within the human brain. Patient inflammatory profiles
were associated with a poorer prognosis, and local anti-inflammatory responses appeared to have a protective role. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Medicina Intensiva. Rio de Janeiro, RJ. Brasil / Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil / Complexo Hospitalar de Niterói. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil / Hospital Quinta D`Or. Rio de Janeiro, TJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Medicina Intensiva. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Laboratório de Bioquímica de Resposta ao Estresse. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Medicina Intensiva. Rio de Janeiro, RJ. Brasil / Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Iron | pt_BR |
Subject | Heme | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Inflammatory response | pt_BR |
Subject | Hemopexin | pt_BR |
Subject | Haptoglobin | pt_BR |
Subject | Central nervous system | pt_BR |
Subject | Subarachnoid hemorrhage | pt_BR |
e-ISSN | 1982-4335 | |