Author | Nicol, Alcina Frederica | |
Author | Fernandes, Ana Teresa Gomes | |
Author | Grinsztejn, Beatriz | |
Author | Russomano, Fábio Bastos | |
Author | E Silva, José Roberto Lapa | |
Author | Tristão, Aparecida | |
Author | Pérez, Mauricio de Andrade | |
Author | Nuovo, Gerard J. | |
Author | Martínez-Maza, Otoniel | |
Author | Bonecini-Almeida, Maria da Gloria | |
Access date | 2019-01-28T15:06:39Z | |
Available date | 2019-01-28T15:06:39Z | |
Document date | 2005 | |
Citation | NICOL, A. F. et al. Distribution of immune cell subsets and cytokine-producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection. Diagnostic Molecular Pathology, v. 14, n. 1, p. 39-47, 2005. | pt_BR |
ISSN | 1052-9551 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31328 | |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | restricted access | pt_BR |
Title | Distribution of immune cell subsets and cytokine-producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/01.pas.0000143309.81183.6c | |
Abstract | The aim of this study was to characterize the immune system profile in the uterine cervix of 17 human papillomavirus (HPV)-infected women, compared with 17 whom were coinfected with HIV-1. Five histologically normal cervices in immunocompetent women were used as controls. HPV infection was associated with a marked increase in cells expressing interleukin (IL)-6, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha). Coinfection by HPV and HIV-1 led to decreased expression of IL-6, TNF-alpha, and IFN-gamma. However, coinfection led to increased numbers of cells expressing IL-4, IL-10, and IL-8. Compared with the histologically normal cervices, increased numbers of macrophages (CD68, RFD7) and T lymphocytes (CD4, CD8) were seen in HPV-infected cervices; coinfection with HIV-1 was associated with a higher number of CD8 cells and lower number of CD68 cells. HPV DNA localized exclusively to the dysplastic squamous cells, whereas HIV-1 RNA was detected mainly in CD68-positive stromal cells. In conclusion, this study shows differential expression of various cytokines and classes of inflammatory cells, relative to HIV-1 infection and HPV coinfection, which may relate to the risk of transmission of HIV-1 and increased risk of cervical cancer in these women. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Clementino Fraga Filho Hospital. Laboratório Multidisciplinar. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University Hospitals. Department of Pathology. Columbus, Ohio, USA. | pt_BR |
Affilliation | David Geffen School of Medicine at UCLA. Immunology & Molecular Genetics. Departments of Obstetrics and Gynecology and Microbiology. Los Angeles, California, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Cytokine | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | in situ PCR | pt_BR |
Subject | Cervical immune response | pt_BR |
Subject | HPV | pt_BR |
Embargo date | 2025-01-01 | |