Author | Jesus, Raphael Amancio de | |
Author | Prado, Vilma Menezes de Jesus | |
Author | Pinto, Vanderson dos Santos | |
Author | Silva, Valdenizia Rodrigues | |
Author | Santos, Luciano S. | |
Author | Nogueira, Paulo C. L. | |
Author | Navickiene, Sandro | |
Author | Pereira Filho, Edenir Rodrigues | |
Author | Blank, Arie Fitzgerald | |
Author | Bezerra, Daniel Pereira | |
Author | Soares, Milena Botelho Pereira | |
Author | Seidl, Claudia | |
Author | Cardoso, Carmen Lúcia | |
Author | Moraes, Valéria Regina de Souza | |
Access date | 2019-01-25T13:33:24Z | |
Available date | 2019-01-25T13:33:24Z | |
Document date | 2018 | |
Citation | JESUS, R. A. et al. Application of LC-DAD Metabolic Fingerprinting in Combination with PCA for Evaluation of Seasonality and Extraction Method on the Chemical Composition of Accessions from Lippia alba (Mill.) N. E. Brown and Biological Activities. Journal of the Brazilian Chemical Society, p. 1-10, 2019. | pt_BR |
ISSN | 0103-5053 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31312 | |
Sponsorship | Coordenação
de Aperfeiçoamento de Pessoal de Nível Superior, Brasil
(CAPES), Finance Code 001. The authors thank the
Brazilian funding agencies CNPq, FAPESB and FAPESP
(PROEM 2014/50299-5, research grant 2013/01710-1 and
Table 2. Inhibition percentage of the activity of the AChE-ICER
Sample
AChE-ICER
inhibition
activity / %
Sample
AChE-ICER
inhibition
activity / %
LA01IS 6.70 ± 0.8 LA01HS 32.7 ± 3.3
LA02IS 14.6 ± 2.4 LA02HS 27.4 ± 0.7
LA24IS 18.0 ± 1.3 LA24HS 30.3 ± 4.1
LA32IS 13.4 ± 0.9 LA32HS 6.70 ± 0.5
LA39IS 17.1 ± 1.7 LA39HS 18.5 ± 4.0
LA54IS 16.1 ± 1.1 LA54HS 24.5 ± 0.7
LA01IW 10.3 ± 4.7 LA01HW 28.4 ± 0.2
LA02IW 7.60 ± 3.8 LA02HW 27.2 ± 0.3
LA24IW 15.0 ± 1.1 LA24HW 24.4 ± 3.2
LA32IW 11.5 ± 1.1 LA32HW 22.2 ± 0.8
LA39IW 23.3 ± 1.6 LA39HW 23.2 ± 1.6
LA54IW 14.4 ± 0.1 LA54HW 29.3 ± 4.5
Galanthaminea 87.4 ± 2.2
aPositive control of acetylcholinesterase (AchE; 100 μM). AChE-ICER:
AChE immobilized enzyme reactor; LA01-LA54: leaf samples of
L. alba accessions; IS: infusion summer; HS: hydroalcoholic summer;
IW: infusion winter; HW: hydroalcoholic winter. PD grant 2014/11640-3) for their financial support and
scholarships. A. F. B., E. R. P. F., D. P. B., C. L. C. and
P. C. L. N. are grateful to CNPq for research fellowships. | pt_BR |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Química | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Lippia alba (Mill.) N. E. Brown | pt_BR |
Subject in Portuguese | Impressão digital LC-DAD | pt_BR |
Subject in Portuguese | PCA | pt_BR |
Subject in Portuguese | Extratos polares | pt_BR |
Subject in Portuguese | Atividades biológicas | pt_BR |
Title | Application of LC-DAD Metabolic Fingerprinting in Combination with PCA for Evaluation of Seasonality and Extraction Method on the Chemical Composition of Accessions from Lippia alba (Mill.) N. E. Brown and Biological Activities | pt_BR |
Type | Article | pt_BR |
DOI | 10.21577/0103-5053.20180244 | pt_BR |
Abstract | The methodology developed in this study through the acquisition of fingerprint chromatograms
by liquid chromatography-diode array detector (LC-DAD), aided by principal component analysis,
made it possible to assess, in a rational way, the chemical differences between six accessions of
Lippia alba and to verify the influence of the method of extraction, the seasonality and the individuality
of each accession on chemical composition of its extracts. Among all extracts analyzed against cancer
cell lines, eight of them showed to be more promising against a human leukemia cell line (HL-60),
displaying cell growth inhibition percentage ranging between 40.0 and 52.0%. In the inhibitory
activity assays against acetylcholinesterase enzyme, all extracts showed weak inhibitory effect,
with highlight only for six of them, which displayed inhibition ranging between 27.0 and 32.0%. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Engenharia Agronômica. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos-SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Engenharia Agronômica. Cristovão, SE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
Affilliation | Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Cristovão, SE, Brasil. | pt_BR |
Subject | Lippia alba (Mill.) N. E. Brown | pt_BR |
Subject | Fingerprint LC-DAD | pt_BR |
Subject | PCA | pt_BR |
Subject | Polar extracts | pt_BR |
Subject | Biological activities | pt_BR |