Author | Santos, Eduardo Caio Torres | |
Author | Santos, Maria Isabel Sampaio | |
Author | Buckner, Frederick S. | |
Author | Yokoyama, Kohei | |
Author | Gelb, Michael | |
Author | Urbina, Julio A. | |
Author | Bergmann, Bartira Rossi | |
Access date | 2019-01-17T09:50:12Z | |
Available date | 2019-01-17T09:50:12Z | |
Document date | 2009 | |
Citation | SANTOS, Eduardo Caio Torres; et al. Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. Journal of Antimicrobial Chemotherapy, v.63, p.469-472, 2009. | pt_BR |
ISSN | 0305-745 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31085 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma | pt_BR |
Subject in Portuguese | metabolismo lipídico | pt_BR |
Subject in Portuguese | Colesterol | pt_BR |
Subject in Portuguese | Cetoconazol | pt_BR |
Title | Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/jac/dkn546 | |
Abstract | The effects of the antileishmanial chalcone 2',6'-dihydroxy-4'-methoxychalcone (DMC) on Leishmania amazonensis sterol composition and biosynthesis were investigated to obtain information about the mechanism of growth inhibition by DMC on this parasite. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of Washington. Department of Medicine. Seattle, WA, USA. | pt_BR |
Affilliation | University of Washington. Department of Chemistry. Seattle, WA, USA. | pt_BR |
Affilliation | University of Washington. Department of Chemistry. Seattle, WA, USA. | pt_BR |
Affilliation | Instituto Venezoelano de Investigaciones Científicas. Caracas, Venezuela. | pt_BR |
Subject | lipid metabolism | pt_BR |
Subject | cholesterol | pt_BR |
Subject | ketoconazole | pt_BR |
Subject | Trypanosoma | pt_BR |
DeCS | Cetoconazol | pt_BR |
e-ISSN | 1460-2091 | |
Embargo date | 2030-01-01 | |