Author | Kochunov, Peter | |
Author | Wey, Hsiao-Ying | |
Author | Fox, Peter | |
Author | Lancaster, Jack | |
Author | Davis, Michael | |
Author | Wang, Danny | |
Author | Lin, Ai-Ling | |
Author | Bastarrachea, Raul | |
Author | Andrade, Marcia | |
Author | Mattern, Vicki | |
Author | Frost, Patrice | |
Author | Higgins, Paul | |
Author | Comuzzie, Anthony | |
Author | Voruganti, Venkata | |
Access date | 2018-12-14T18:23:28Z | |
Available date | 2018-12-14T18:23:28Z | |
Document date | 2017 | |
Citation | KOCHUNOV, Peter et al. Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.). Frontiers in Neuroscience. v. 11, p. 1-12, fev. 2017. | pt_BR |
ISSN | 1662-4548 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30600 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Desafio Hiperglicêmico | pt_BR |
Subject in Portuguese | Fluxo Sanguíneo Cerebral | pt_BR |
Subject in Portuguese | Imagem de Perfusão | pt_BR |
Subject in Portuguese | Rede de Estado de Repouso | pt_BR |
Subject in Portuguese | Rede de Estado Padrão | pt_BR |
Subject in Portuguese | Rotulagem da Rotação Arterial | pt_BR |
Title | Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.) | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fnins.2017.00049 | |
Abstract | Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38.9 mg/dL and declined to 133.4 ± 22.0 mg/dL, at the end of the experiment. Regional CBF changes consisted of four clusters: cerebral cortex, thalamus, hypothalamus, and mesencephalon. Increases in the hypothalamic blood flow occurred concurrently with the regulatory response to systemic glucose change, whereas CBF declined for other clusters. The return to baseline of hypothalamic blood flow was observed while CBF was still increasing in other brain regions. The spatial pattern of extra-hypothalamic CBF changes was correlated with the patterns of several cerebral networks including the default mode network. These findings suggest that hypothalamic blood flow response to systemic glucose levels can potentially be explained by regulatory activity. The response of extra-hypothalamic clusters followed a different time course and its spatial pattern resembled that of the default-mode network. | pt_BR |
Affilliation | Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MA, USA / Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Southwest National Primate Research Center, San Antonio, TX, USA. | pt_BR |
Affilliation | Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. | pt_BR |
Affilliation | Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. | pt_BR |
Affilliation | Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. | pt_BR |
Affilliation | Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. | pt_BR |
Affilliation | Ahmanson-Lovelace Brain Mapping Center, University of California at Los Angeles, Los Angeles, CA, USA / Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. | pt_BR |
Affilliation | Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. | pt_BR |
Affilliation | Southwest National Primate Research Center, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. | pt_BR |
Affilliation | Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. | pt_BR |
Affilliation | Southwest National Primate Research Center, San Antonio, TX, USA. | pt_BR |
Affilliation | Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. | pt_BR |
Affilliation | Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. | pt_BR |
Affilliation | Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. | pt_BR |
Subject | Hyperglycemic Challenge | pt_BR |
Subject | Cerebral Blood Flow | pt_BR |
Subject | Perfusion Imaging | pt_BR |
Subject | Resting State Network | pt_BR |
Subject | Default State Network | pt_BR |
Subject | Arterial Spin Labeling | pt_BR |
e-ISSN | 1662-453X | |