Author | Nicol, Alcina Frederica | pt_BR |
Author | Nuovo, Gerard J. | pt_BR |
Author | Salomão-Estevez, Arthur | pt_BR |
Author | Grinsztejn, Beatriz | pt_BR |
Author | Tristão, Aparecida | pt_BR |
Author | Russomano, Fábio Bastos | pt_BR |
Author | Silva, José Roberto Lapa e | pt_BR |
Author | Oliveira, Marcia P. de | pt_BR |
Author | Pirmez, Claude | pt_BR |
Access date | 2018-12-13T15:09:35Z | |
Available date | 2018-12-13T15:09:35Z | |
Document date | 2007 | |
Citation | NICOL, Alcina Frederica et al. Immune factors involved in the cervical immune response in the HIV/HPV co-infection. Journal of Clinical Pathology, v. 61, n. 1, p. 84-88, 25 May 2007. | pt_BR |
ISSN | 0021-9746 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30577 | |
Language | eng | pt_BR |
Publisher | BMJ | pt_BR |
Rights | restricted access | |
Title | Immune factors involved in the cervical immune response in the HIV/HPV co-infection | pt_BR |
Type | Article | |
DOI | 10.1136/jcp.2007.047290 | |
Abstract | Aims: Immune factors influencing the progression of cervical intraepithelial neoplasia (CIN) to cancer remain poorly defined. This study investigates the expression of RANTES, MIP1a, COX1, COX2, STAT3, TGFbRI, IL10R, TNFaRII and TLR4 in the cervical immune response in HIV/HPV (human papillomavirus) co-infected women. Methods: Cervical biopsies of 36 patients were assayed by immunohistochemistry, and the Ventana Benchmark System was used for HIV-nef detection. Results: Cervices from HIV-positive patients exhibited nef in cells mainly around blood vessels, and showed a decreased expression of all the immune factors tested except IL10R and STAT3, while RANTES (5.54 cells/mm2) was highly expressed in comparison with controls (1.41 cells/mm2, p = 0.028). COX1 was decreased in the HIV/HPV- (0.32 cells/mm2, p = 0.017) and HPV-infected patients (0.21 cells/mm2, p = 0.015) compared with controls (3.28 cells/mm2). Conclusions: It is suggested that RANTES in HIV/HPV co-infection may influence the development of CIN leading to progression to cervical cancer. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University Hospitals. Department of Pathology. Columbus, OH, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | HPV | pt_BR |
Subject | Disease Progression | pt_BR |
Subject | Cervical Intraepithelial Neoplasia | pt_BR |
Subject | Cyclooxygenase 1 | pt_BR |
Subject | Chemokine CCL5 | pt_BR |
Subject | Papillomavirus Infections | pt_BR |
Subject | Uterine Cervical Neoplasms | pt_BR |
Embargo date | 2028-08-30 | |