Author | Ratcliffe, Norman A. | |
Author | Mello, Cicero B. | |
Author | Garcia, Eloi S. | |
Author | Butt, Tariq M. | |
Author | Azambuja, Patricia | |
Access date | 2018-11-27T15:17:39Z | |
Available date | 2018-11-27T15:17:39Z | |
Document date | 2011 | |
Citation | RATCLIFFE, Norman A. et al. Insect natural products and processes: New treatments for human disease. Insect Biochemistry and Molecular Biology, v.41, p.747-769, 2011. | pt_BR |
ISSN | 0965-1748 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30258 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Produtos naturais de insetos | pt_BR |
Subject in Portuguese | Medicina Tradicional | pt_BR |
Subject in Portuguese | Mel | pt_BR |
Subject in Portuguese | Medicamentos | pt_BR |
Subject in Portuguese | Veneno | pt_BR |
Subject in Portuguese | Seda | pt_BR |
Subject in Portuguese | Larvas | pt_BR |
Subject in Portuguese | Fatores antimicrobianos | pt_BR |
Subject in Portuguese | Anticoagulantes | pt_BR |
Subject in Portuguese | Agentes anti-câncer | pt_BR |
Title | Insect natural products and processes: new treatments for human disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ibmb.2011.05.007 | |
Abstract | In this overview, some of the more significant recent developments in bioengineering natural products from insects with use or potential use in modern medicine are described, as well as in utilisation of insects as models for studying essential mammalian processes such as immune responses to pathogens. To date, insects have been relatively neglected as sources of modern drugs although they have provided valuable natural products, including honey and silk, for at least 4-7000 years, and have featured in folklore medicine for thousands of years. Particular examples of Insect Folk Medicines will briefly be described which have subsequently led through the application of molecular and bioengineering techniques to the development of bioactive compounds with great potential as pharmaceuticals in modern medicine. Insect products reviewed have been derived from honey, venom, silk, cantharidin, whole insect extracts, maggots, and blood-sucking arthropods. Drug activities detected include powerful antimicrobials against antibiotic-resistant bacteria and HIV, as well as anti-cancer, anti-angiogenesis and anti-coagulant factors and wound healing agents. Finally, the many problems in developing these insect products as human therapeutic drugs are considered and the possible solutions emerging to these problems are described. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Swansea University. College of Science. Department of Biosciences,. Swansea, Wales, UK. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Swansea University. College of Science. Department of Biosciences,. Swansea, Wales, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Insect natural products | pt_BR |
Subject | Medicinal drugs | pt_BR |
Subject | Folk medicine | pt_BR |
Subject | Honey | pt_BR |
Subject | Venom | pt_BR |
Subject | Silk | pt_BR |
Subject | Cantharidin | pt_BR |
Subject | Maggots | pt_BR |
Subject | Antimicrobial factors | pt_BR |
Subject | Anticoagulants | pt_BR |
Subject | Anti-cancer agents | pt_BR |
e-ISSN | 1879-0240 | |
Embargo date | 2030-01-01 | |