Author | D'Avila, Heloisa | |
Author | Lima, Célio G. Freire de | |
Author | Roque, Natalia R. | |
Author | Teixeira, Livia | |
Author | Barja-Fidalgo, Christina | |
Author | Silva, Adriana R. | |
Author | Melo, Rossana C. N. | |
Author | Dosreis, George A. | |
Author | Faria Neto, Hugo C. Castro | |
Author | Bozza, Patrícia T. | |
Access date | 2018-11-18T13:57:52Z | |
Available date | 2018-11-18T13:57:52Z | |
Document date | 2011 | |
Citation | D`Avila, Heloisa; et al. Host Cell Lipid Bodies Triggered by Trypanosoma cruzi Infection and Enhanced by the Uptake of Apoptotic Cells Are Associated With Prostaglandin E2 Generation and Increased Parasite Growth. The Journal of Infectious Diseases, v.204, p.951–61, 2011. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30073 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Corpos lipídicos | pt_BR |
Subject in Portuguese | células hospedeiras | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Células Apoptóticas | pt_BR |
Subject in Portuguese | Prostaglandina E2 | pt_BR |
Subject in Portuguese | Crescimento de Parasita Aumentado | pt_BR |
Title | Host cell lipid bodies triggered by Trypanosoma cruzi infection and enhanced by the uptake of apoptotic cells are associated with prostaglandin E₂ generation and increased parasite growth | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jir432 | |
Abstract | Lipid bodies (lipid droplets) are lipid-rich organelles with functions in cell metabolism and signaling. Here, we investigate the mechanisms of Trypanosoma cruzi-induced lipid body formation and their contributions to host-parasite interplay. We demonstrate that T. cruzi-induced lipid body formation in macrophages occurs in a Toll-like receptor 2-dependent mechanism and is potentiated by apoptotic cell uptake. Lipid body biogenesis and prostaglandin E₂ (PGE₂) production triggered by apoptotic cell uptake was largely dependent of α(v)β₃ and transforming growth factor-β signaling. T. cruzi-induced lipid bodies act as sites of increased PGE synthesis. Inhibition of lipid body biogenesis by the fatty acid synthase inhibitor C75 reversed the effects of apoptotic cells on lipid body formation, eicosanoid synthesis, and parasite replication. Our findings indicate that lipid bodies are highly regulated organelles during T. cruzi infection with roles in lipid mediator generation by macrophages and are potentially involved in T. cruzi-triggered escape mechanisms. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Departamento de Biologia. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Juiz de Fora. Departamento de Biologia. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Farmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Biologia. Laboratório de Biologia Celular. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi infection | pt_BR |
Subject | Lipid Bodies | pt_BR |
Subject | Apoptotic Cells | pt_BR |
Subject | Prostaglandin E2 Generation | pt_BR |
Subject | increased Parasite Growth | pt_BR |
e-ISSN | 1537-6613 | |
Embargo date | 2030-01-01 | |