Author | Faria Neto, Hugo Caire Castro | |
Author | Múltipla autoria - ver em Notas | |
Access date | 2018-11-08T15:50:28Z | |
Available date | 2018-11-08T15:50:28Z | |
Document date | 2012 | |
Citation | VIEIRA, Rodolfo de Paula et al. Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution. Medicine & Science in Sports & Exercise, v. 44, n. 7, p.1227-1234, 2012. | pt_BR |
ISSN | 0195-9131 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29965 | |
Description | AUTHORS - RODOLFO DE PAULA VIEIRA1,2, ALESSANDRA CHOQUETA TOLEDO3, LUCAS BOGAZ SILVA1,
FRANCINE MARIA ALMEIDA3, NILSA REGINA DAMACENO-RODRIGUES4, ELIA GARCIA CALDINI4,
ANGELA BATISTA GOMES SANTOS1, DOLORES HELENA RIVERO1, DEBORAH CAMARGO HIZUME3,
FERNANDA DEGOBBI TENO´ RIO QUIRINO SANTOS LOPES3, CLARICE ROSA OLIVO3,
HUGO CAIRE CASTRO-FARIA-NETO 5, MILTON ARRUDA MARTINS3,
PAULO HILÁRIO NASCIMENTO SALDIVA1, and MARISA DOLHNIKOFF1 - AFFILIATIONS - 1Laboratory of Experimental Air Pollution (LIM 05), Department of Pathology, University of Sa˜o Paulo, School of
Medicine, Sa˜o Paulo, BRAZIL; 2Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho
University, Sa˜o Paulo, BRAZIL; 3Laboratory of Experimental Therapeutics (LIM 20), Department of Clinical Medicine,
School of Medicine, University of Sa˜o Paulo, Sa˜o Paulo, BRAZIL; 4Laboratory of Cellular Biology (LIM 59),
Department of Pathology, School of Medicine, University of Sa˜o Paulo, Sa˜o Paulo, BRAZIL; and 5 Laboratory of
Immunopharmacology, Oswaldo Cruz Foundation, Institute Oswaldo Cruz, Rio de Janeiro, BRAZIL. | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Treinamento aeróbico | pt_BR |
Subject in Portuguese | Imunologia | pt_BR |
Subject in Portuguese | Inflamação pulmonar | pt_BR |
Subject in Portuguese | estresse oxidativo | pt_BR |
Subject in Portuguese | estresse nitrosativo | pt_BR |
Title | Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution | pt_BR |
Type | Article | pt_BR |
DOI | 10195-9131/12/4407-1227/0 | |
Abstract | Purpose: Exposure to diesel exhaust particles (DEP) results in lung inflammation.
Regular aerobic exercise improves the inflammatory status in different pulmonary diseases. However, the effects of long-term aerobic
exercise on the pulmonary response to DEP have not been investigated. The present study evaluated the effect of aerobic conditioning
on the pulmonary inflammatory and oxidative responses of mice exposed to DEP. Methods: BALB/c mice were subjected to aerobic
exercise five times per week for 5 wk, concomitantly with exposure to DEP (3 mgImLj1; 10 KL per mouse). The levels of exhaled nitric
oxide, reactive oxygen species, cellularity, interleukin 6 (IL-6), and tumor necrosis factor > (TNF->) were analyzed in bronchoalveolar
lavage fluid, and the density of neutrophils and the volume proportion of collagen fibers were measured in the lung parenchyma. The
cellular density of leukocytes expressing IL-1A, keratinocyte chemoattractant (KC), and TNF-> in lung parenchyma was evaluated with
immunohistochemistry. The levels of IL-1A, KC, and TNF-> were also evaluated in the serum. Results: Aerobic exercise inhibited the
DEP-induced increase in the levels of reactive oxygen species (P G 0.05); exhaled nitric oxide (P G 0.01); total (P G 0.01) and differential
cells (P G 0.01); IL-6 and TNF-> levels in bronchoalveolar lavage fluid (P G 0.05); the level of neutrophils (P G 0.001); collagen density
in the lung parenchyma (P G 0.05); the levels of IL-6, KC, and TNF-> in plasma (P G 0.05); and the expression of IL-1A, KC, and TNF->
by leukocytes in the lung parenchyma (P G 0.01). Conclusions: We conclude that long-term aerobic exercise presents protective effects
in a mouse model of DEP-induced lung inflammation. Our results indicate a need for human studies that evaluate the pulmonary
responses to aerobic exercise chronically performed in polluted areas. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Múltipla autoria - ver em Notas (Afiliações) | pt_BR |
Subject | Aerobic training | pt_BR |
Subject | immunology | pt_BR |
Subject | lung inflammation | pt_BR |
Subject | diesel exhaust particles | pt_BR |
Subject | nitrosative stress | pt_BR |
Subject | oxidative stress | pt_BR |
e-ISSN | 1530-0315 | |
Embargo date | 2030-01-01 | |