Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/29724
Type
ArticleCopyright
Restricted access
Embargo date
2030-01-01
Collections
Metadata
Show full item record
HEPATITIS D INFECTION IN BRAZIL: PREVALENCE AND GEOGRAPHICAL DISTRIBUTION OF ANTI-DELTA ANTIBODY
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Universidade Estadual Paulista. Laboratório de Biologia Molecular, Faculdade de Medicina. Divisão Homocentro. Campus de Botucatu. Botucatu, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
The Brazilian Hepatitis B Research Group
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Universidade Estadual Paulista. Laboratório de Biologia Molecular, Faculdade de Medicina. Divisão Homocentro. Campus de Botucatu. Botucatu, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
The Brazilian Hepatitis B Research Group
Abstract
In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however,
studies in other regions of the country are scarce. This study aims to map the
seroepidemiological situation of anti-Delta antibodies in chronic hepatitis B carriers in
all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive
individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states
were tested for the presence of anti-Delta antibodies using a commercial
immunoassay. Anti-Delta antibodies were detected in 40 samples (3.2%; 52.5%
female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly
associated with anti-HDV positivity (P < 0.001). The distribution of anti-Delta differed
markedly in the diverse regions of the country. The highest prevalence of anti-HDV
was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast
(1.7%), Northeast (0.8%), and South (0.0%). Anti-Delta antibodies were detected in 12
states, but more than 60%of the positive cases were observed in two states, Amazonas
and Acre, located in the western portion of the Amazon region. The overall HDV
prevalence of 3.2% emphasizes that HDV is far from being a disease under control in
Brazil. Despite the low HDV prevalence in non-endemic regions, this infection persists
as a major concern in two states (Acre and Amazonas) in the north of the country,
indicating that a continuous epidemiological surveillance program should be
implemented in all Brazilian regions.
Share