Author | Carli, Salvina Mariade Campos | |
Author | Araújo, Marcio Sobreira | |
Author | Silveira, Amanda Cardoso de Oliveira | |
Author | Rezende, Vítor Bortolo de | |
Author | Rocha, Natalia Pessoa | |
Author | Ferretjans, Rodrigo | |
Author | Santos, Rafael Ribeiro | |
Author | Carvalho, Andrea Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Author | Berke, Michael | |
Author | Salgado, João Vinícius | |
Author | Teixeira, Antonio Lucio | |
Access date | 2018-10-09T18:08:30Z | |
Available date | 2018-10-09T18:08:30Z | |
Document date | 2017 | |
Citation | CARLI, Salvina Maria de Campos et al. Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms. J Psychiatr Res., v. 87, p. 44-52, 2017 | pt_BR |
ISSN | 0022-3956 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29478 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Receptores canabinoides | pt_BR |
Subject in Portuguese | citocinas | pt_BR |
Subject in Portuguese | Sistema endocanabinóide | pt_BR |
Subject in Portuguese | inflamação | pt_BR |
Subject in Portuguese | leucocitos | pt_BR |
Subject in Portuguese | esquizofrenia | pt_BR |
Title | Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jpsychires.2016.12.001 | |
Abstract | OBJECTIVES: to evaluate cannabinoid receptors (CBRs) expression on peripheral immune cells, i.e., blood monocytes, neutrophils, lymphocytes, and NK cells, and their relationship to a wide range of serum cytokine levels in subjects with schizophrenia and controls.
METHODS: A sample of 55 people with chronic schizophrenia and 48 controls were enrolled in the study. The expression of the cannabinoid receptors CB1R and CB2R was evaluated in peripheral blood leukocytes by flow cytometry. Serum levels of cytokines/chemokines were simultaneously analyzed by cytometric bead array.
RESULTS: We found higher expression of cannabinoid receptors on cells of the innate immune system in subjects with schizophrenia when compared with controls. Serum levels of interleukin-4 (IL-4), IL-6, IL-10, IL-17, interferon (IFN-γ), and (C-X-C motif) ligand 10/interferon gamma-induced protein 10 (CXCL10/IP10) were decreased, while levels of the chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) were increased in the schizophrenia group in comparison with controls. Patients with schizophrenia showed simpler correlation network between cytokines and CBRs expression than controls.
CONCLUSION: Patients with schizophrenia showed increased CBRs expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls. These results suggest a defective endocannabinoid system-mediated immunomodulation in patients with schizophrenia. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório Interdisciplinar de Investigação Médica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório Interdisciplinar de Investigação Médica. Belo Horizonte, MG, Brazil/Translational Psychiatry Program. Department of Psychiatry and Behavioral Sciences. The University of Texas Health Science Center at Houston. Houston, TX, USA | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório Interdisciplinar de Investigação Médica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Estado de Minas Gerais. Fundação Hospitalar. Instituto Raul Soares. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Orygen, The National Centre of Excellence in Youth Mental Health. Department of Psychiatry and The Florey Institute of Neuroscience and Mental Health. The University of Melbourne. Parkville, Australia | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório Interdisciplinar de Investigação Médica. Belo Horizonte, MG, Brazil/Estado de Minas Gerais. Fundação Hospitalar. Instituto Raul Soares. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório Interdisciplinar de Investigação Médica. Belo Horizonte, MG, Brazil/Estado de Minas Gerais. Fundação Hospitalar. Instituto Raul Soares. Belo Horizonte, MG, Brazil | pt_BR |
Subject | Cannabinoid receptors | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Endocannabinoid system | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Leukocytes | pt_BR |
Subject | Schizophrenia | pt_BR |
Embargo date | 2022-01-01 | |