Author | Pérez, Ana Rosa | |
Author | Morrot, Alexandre | |
Author | Carvalho, Vinicius Frias | |
Author | Meis, Juliana de | |
Author | Savino, Wilson | |
Access date | 2018-10-09T12:56:16Z | |
Available date | 2018-10-09T12:56:16Z | |
Document date | 2018 | |
Citation | PÈREZ, Ana Rosa; et al. Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions. Frontiers in Endocrinology, v.9, Article 334, 8p, June 2018. | pt_BR |
ISSN | 1664-2392 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29453 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | atrofia do timo | pt_BR |
Subject in Portuguese | prolactina | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | hormonio de crescimento | pt_BR |
Subject in Portuguese | timócitos | pt_BR |
Subject in Portuguese | eixo hipotálamo-hipófise-adrenal | pt_BR |
Title | Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fendo.2018.00334 | |
Abstract | T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease. | pt_BR |
Affilliation | Institute of Clinical and Experimental Immunology. Rosario, Argentina. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Centro de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | thymus atrophy | pt_BR |
Subject | thymocytes | pt_BR |
Subject | hypothalamus–pituitary–adrenal axis | pt_BR |
Subject | growth hormone | pt_BR |
Subject | prolactin | pt_BR |