Autor | Montoya, Dennis | |
Autor | Cruz, Daniel | |
Autor | Teles, Rosane M. B. | |
Autor | Lee, Delphine J. | |
Autor | Ochoa, Maria Teresa | |
Autor | Krutzik, Stephan R. | |
Autor | Chun, Rene | |
Autor | Schenk, Mirjam | |
Autor | Zhang, Xiaoran | |
Autor | Ferguson, Benjamin G. | |
Autor | Burdick, Anne E. | |
Autor | Sarno, Euzenir N. | |
Autor | Rea, Thomas H. | |
Autor | Hewison, Martin | |
Autor | Adams, John S. | |
Autor | Cheng, Genhong | |
Autor | Modlin, Robert L. | |
Data de acesso | 2018-09-25T17:42:32Z | |
Data de disponibilização | 2018-09-25T17:42:32Z | |
Data do publicação | 2009 | |
Citação | MONTOYA, Dennis; et al. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. v. 6, n.4, p.343–353., Oct. 2009. | pt_BR |
ISSN | 1931-3128 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29052 | |
Idioma | eng | pt_BR |
Editor | Elsevier | pt_BR |
Direito Autoral | restricted access | pt_BR |
Palavras-chave | Hanseníase | pt_BR |
Palavras-chave | Imunidade Inata | pt_BR |
Palavras-chave | Infecções Bacterianas | pt_BR |
Palavras-chave | macrófagos fagocitários | pt_BR |
Palavras-chave | programas antimicorbianos | pt_BR |
Título | Divergence of macrophage phagocytic and antimicrobial programs in leprosy | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | 10.1016/j.chom.2009.09.002 | |
Resumo em Inglês | Effective innate immunity against many microbial pathogens requires macrophage programs that upregulate phagocytosis and direct antimicrobial pathways, two functions generally assumed to be coordinately regulated. We investigated the regulation of these key functions in human blood-derived macrophages. Interleukin-10 (IL-10) induced the phagocytic pathway, including the C-type lectin CD209 and scavenger receptors, resulting in phagocytosis of mycobacteria and oxidized low-density lipoprotein. IL-15 induced the vitamin D-dependent antimicrobial pathway and CD209, yet the cells were less phagocytic. The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of the disease, whereas the vitamin D-dependent antimicrobial pathway predominated in the self-limited form and in patients undergoing reversal reactions from the multibacillary to the self-limited form. These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Division of Cardiology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of Miami School of Medicine. Department of Dermatology and Cutaneous Surgery. Miami, FL, USA. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de |Micobactérias. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliação | University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA. | pt_BR |
Afiliação | University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA / University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA. | pt_BR |
Palavras-chave em inglês | Leprosy | pt_BR |
Palavras-chave em inglês | antimicrobial programs | pt_BR |
Palavras-chave em inglês | macrophage phagocytic | pt_BR |
Palavras-chave em inglês | innate immunity | pt_BR |
Palavras-chave em inglês | bacterial infections | pt_BR |
e-ISSN | 1934-6069 | |
Data de embargo | 2030-01-01 | |