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IMPLICATIONS OF HIGH LEVEL PSEUDOGENE TRANSCRIPTION IN MYCOBACTERIUM LEPRAE
Author
Affilliation
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA.
Rocky Mountain Regional Center of Excellence. Department of Microbiology, Immunology & Pathology. Colorado State University. Fort Collins, CO, USA.
Rocky Mountain Regional Center of Excellence. Department of Microbiology, Immunology & Pathology. Colorado State University. Fort Collins, CO, USA.
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA.
Center for Advanced Research in Public Health. CSISP, Area de Genomica y Salud. Valencia, Spain.
Indian Institute of Science. Department of Microbiology and Cell Biology. Bangalore, India.
Indian Institute of Science. Department of Microbiology and Cell Biology. Bangalore, India.
Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA.
Rocky Mountain Regional Center of Excellence. Department of Microbiology, Immunology & Pathology. Colorado State University. Fort Collins, CO, USA.
Rocky Mountain Regional Center of Excellence. Department of Microbiology, Immunology & Pathology. Colorado State University. Fort Collins, CO, USA.
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA.
Center for Advanced Research in Public Health. CSISP, Area de Genomica y Salud. Valencia, Spain.
Indian Institute of Science. Department of Microbiology and Cell Biology. Bangalore, India.
Indian Institute of Science. Department of Microbiology and Cell Biology. Bangalore, India.
Johns Hopkins School of Medicine. Division of Infectious Diseases. Department of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
HRSA, BPHC, Division of National Hansen's Disease Programs. Laboratory Research Branch. Molecular Biology Research Department. School of Veterinary Medicine. Louisiana State University. Baton Rouge, LA, USA.
Abstract
The Mycobacterium leprae genome has less than 50% coding capacity and 1,133 pseudogenes. Preliminary evidence suggests that some pseudogenes are expressed. Therefore, defining pseudogene transcriptional and translational potentials of this genome should increase our understanding of their impact on M. leprae physiology.
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