Author | Araújo, Ana Ruth | |
Author | Magalhães, Vanessa Peruhype | |
Author | Reis, Jordana Grazziela Alves Coelho dos | |
Author | Chaves, Laura Patrícia Viana | |
Author | Lima, Tatiane Amábili de | |
Author | Pimentel, João Paulo Diniz | |
Author | Paula, Lúcia de | |
Author | Almeida, Carlos Maurício de | |
Author | Tarragô, Andréa Monteiro | |
Author | Tateno, Adriana | |
Author | Carvalho, Andrea Teixeira de | |
Author | Martins Filho, Olindo de Assis | |
Author | Lira, Edson da Fonseca | |
Author | Torres, Kátia Luz | |
Author | Talharia, Sinésio | |
Author | Malheiro, Adriana | |
Access date | 2018-09-25T14:12:18Z | |
Available date | 2018-09-25T14:12:18Z | |
Document date | 2013 | |
Citation | ARAÚJO, Ana Ruth et al. Dual role of IL-12 in the therapeutic efficacy or failure during combined PEG-Interferon-α2A and ribavirin therapy in patients with chronic hepatitis C. Immunology Letters, v. 154, n. 1-2, p. 61-69, 2013 | pt_BR |
ISSN | 0165-2478 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29039 | |
Language | eng | pt_BR |
Publisher | Elsevier/North-Holland Biomedical Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | citocinas | pt_BR |
Subject in Portuguese | HCV | pt_BR |
Title | Dual role of IL-12 in the therapeutic efficacy or failure during combined PEG-Interferon-α2A and ribavirin therapy in patients with chronic hepatitis C | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.imlet.2013.07.010 | |
Abstract | Several efforts have been made to establish novel biomarkers with relevant predictive values to monitor HCV-infected patients under pegilated Interferon-α2A-(PEG-IFN-α2A)/ribavirin therapy. The aim of this study was to monitor the kinetics of HCV viral load, serum levels of pro-inflammatory/regulatory cytokines and leukocyte activation status before and after PEG-IFN-α2A/ribavirin therapy in 52 volunteers, including 12 chronic HCV patients and 40 controls. The HCV viral load, serum levels of cytokines (IL-8/IL-6/TNF-α/IL-12/IFN-γ/IL-4/IL-10) and the phenotype of peripheral blood leukocytes were evaluated before and after 4, 12 and 24 weeks following the PEG-IFN-α2A/ribavirin therapy. Our results demonstrated that sustained virological response-(SVR) is associated with early decrease in the viral load after 4 weeks of treatment. The presence of a modulated pro-inflammatory profile at baseline favors SVR, whereas a strong inflammatory response at baseline predisposes to therapeutic failure. Furthermore, a time-dependent increase on serum IL-12 levels in patients under treatment is critical to support the SVR, while the early predominance of IL-10 correlates to late virological relapse. On the other hand, a broad but unguided "cytokine storm" is observed in the non-responder HCV patients after 12 weeks of treatment. Corroborating these findings, monocyte/lymphocyte activation at baseline is associated with the non-responders to therapy whereas high CD8(+) T-cell numbers associate with SVR. All in all, these data suggest that the baseline pattern of serum pro-inflammatory/regulatory cytokines and the immunological activation status of chronic HCV patients undergoing PEG-IFN-α2A/ribavirin therapy are closely related with the therapeutic response. | pt_BR |
Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Manaus, AM, Brazil/Universidade Federal do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Manaus, AM, Brazil/Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brazil/Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil/ Fundação Oswaldo Cruz. Centro de Pesquisas Leonidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brazil/ Fundação Alfredo da Matta. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brazil/Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade do Estado do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Manaus, AM, Brazil/Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Subject | Cytokines | pt_BR |
Subject | HCV | pt_BR |
Subject | HCV non-responder | pt_BR |
Subject | HCV-NR | pt_BR |
Subject | PEG-IFN-α2A | pt_BR |
Subject | PEG-IFN-α2A/ribavirin | pt_BR |
Subject | SVR | pt_BR |
Subject | Sustained virological response | pt_BR |
Subject | Viral load | pt_BR |
Subject | pegilated Interferon-α2A | pt_BR |
Subject | sustained virological load | pt_BR |
Embargo date | 2020-01-01 | |