Author | De Boni, Raquel B. | |
Author | Peratikos, Meridith B. | |
Author | Shepherd, Bryan E. | |
Author | Grinsztejn, Beatriz | |
Author | Cortés, Claudia | |
Author | Padgett, Denis | |
Author | Gotuzzo, Eduardo | |
Author | Belaunzarán-Zamudio, Pablo F. | |
Author | Rebeiro, Peter F. | |
Author | Duda, Stephany N. | |
Author | McGowan, Catherine C. | |
Access date | 2018-09-19T17:11:55Z | |
Available date | 2018-09-19T17:11:55Z | |
Document date | 2018 | |
Citation | DE BONI, Raquel B. et al. Is Substance Use Associated with HIV Cascade Outcomes in Latin America? PLoS ONE, v. 13, n. 3, p. 1-15, Mar. 2018. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28904 | |
Description | CCASAnet - The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) brings together the expertise and resources of Vanderbilt University and clinical and research sites in Argentina, Brazil, Chile, Haiti, Honduras, Mexico and Peru. | pt_BR |
Sponsorship | This work was supported by the NIHfunded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International epidemiology Databases to Evaluate AIDS (leDEA) (U01-AI069923). This award is funded by the following institutes: Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Cancer Institute (NCI), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Mental Health (NIMH), and the Office Of The Director, National Institutes Of Health (OD). The work of Pablo F Belaunzaran Zamudio is supported by the División de Investigación de la Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Is substance use associated with HIV cascade outcomes in Latin America? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0194228 | |
Abstract | Background: The HIV care cascade has improved in Latin America over the last decade. However, the influence of alcohol and noninjected drug use (NIDU) on cascade outcomes is mostly unknown. This study estimated the association of alcohol and NIDU with retention in care, loss to follow up (LTFU), and virologic failure (VF). Methods: Individuals ≥18 years attending routine HIV clinic visits and completing the Rapid Screening Tool (RST; evaluating NIDU and ART adherence in 7-day recall period) during 2012-13 were followed up to 2015 in the Caribbean, Central and South America network for HIV epidemiology. Adjusted odds ratios (aOR) were calculated for the association of alcohol consumption and NIDU with retention in care by logistic regression; adjusted hazard ratios (aHR) were estimated for the associations with LTFU and VF by Cox regression. Results: Among 3604 individuals, the proportions retained in care for one year were 84%, 79%, 72%, and 69% for patients reporting non-use, alcohol use, NIDU, and both alcohol and NIDU, respectively. For the same patient groups, the proportions LTFU over 18 months were 6%, 8%, 12%, and 13%, respectively. There were 1901 patients (53%) with HIV RNA results; VF proportions were similar between users and nonusers (ranging from 14-16%). After controlling for age, sex, study site, HIV transmission mode, time on ART, AIDS status, and CD4 count, neither alcohol use (aOR = 1.1, CI = 0.9-1.4; aHR = 1.0, CI = 0.8-1.3) nor NIDU (aOR = 1.3, CI = 0.9-1.8; aHR = 1.4, CI = 0.9-2.1) were significantly associated with retention or VF, respectively. However, both alcohol use (aHR = 1.2, CI = 1.02-1.4) and NIDU (aHR = 1.3, CI = 1.00-1.8) were associated with increased LTFU. Conclusion: Alcohol use and NIDU in a 7-day recall period increased the risk of being LTFU during the next 18 months, highlighting the need for routine screening and targeted interventions to keep these individuals in care and on ART. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Vanderbilt University Medical Center. Nashville, TN, USA. | pt_BR |
Affilliation | Vanderbilt University Medical Center. Nashville, TN, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundación Arriaran-Facultad de Medicina Universidad de Chile. Santiago, Chile. | pt_BR |
Affilliation | Instituto Hondureno de Seguridad Social and Hospital Escuela. Tegucigalpa, Honduras. | pt_BR |
Affilliation | Universidad Peruana Cayetano Heredia. Lima, Peru. | pt_BR |
Affilliation | Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico. | pt_BR |
Affilliation | Vanderbilt University Medical Center. Nashville, TN, USA. | pt_BR |
Affilliation | Vanderbilt University Medical Center. Nashville, TN, USA. | pt_BR |
Affilliation | Vanderbilt University Medical Center. Nashville, TN, USA. | pt_BR |
Subject | HIV | |
Subject | HIV infection treatment | |
Subject | HIV diagnosis | |
Subject | Latin America | |