Author | Stimamiglio, Marco Augusto | |
Author | Barbosa, Suse Dayse Silva | |
Author | Domingues, Maria Aparecida Custódio | |
Author | Trentin, Andréa Gonçalves | |
Author | Silva, Marcio Alvarez | |
Author | Savino, Wilson | |
Access date | 2018-08-21T13:31:10Z | |
Available date | 2018-08-21T13:31:10Z | |
Document date | 2008 | |
Citation | STIMAMIGLIO, Marco Augusto; et al. Is there a role for fibronectin upon true histiocytic lymphoma progression?. International Journal of Oncology, v.33, p.517-524, 2008. | pt_BR |
ISSN | 1019-6439 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28266 | |
Language | eng | pt_BR |
Publisher | Spandidos Publications | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Fibronectinas | pt_BR |
Subject in Portuguese | infonodos | pt_BR |
Subject in Portuguese | Matriz extracelular | pt_BR |
Title | Is there a role for fibronectin upon true histiocytic lymphoma progression? | pt_BR |
Type | Article | pt_BR |
DOI | 10.3892/ijo_00000035 | |
Abstract | Cell interaction with extracellular matrix is a
crucial event for various biological processes, including tumor
progression. Although not exclusively, these interactions
are frequently mediated by bidirectional signaling receptors
known as integrins. Using a human histiocytic lymphomaderived
cell line (U-937), we evaluated the effects of ECM
proteins and their integrin-type receptors in the regulation
of cell attachment, proliferation, migration and survival.
Fibronectin induces higher cell attachment in vitro when
compared to laminin. Fibronectin also promotes a decrease
in cell migration but do not modulate cell proliferation and
death. Pre-incubation of U-937 cells with VLA-5 antagonistic
peptides inhibited attachment of the cells to fibronectincoated
substrates. In a second vein, we observed that lymph
node specimens obtained from diagnosed patient for true
histiocytic lymphoma had greater deposition of fibronectin
(but not laminin) around malignant clones. These results
suggest that fibronectins play a relevant role in the establishment
and progression of true histiocytic lymphoma cells. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Centro de Hematologia e Hemoterapia de Santa Catarina. Laboratório de Hemopatologia. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Biologia Celular, Embriologia e Genética. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | histiocytic lymphoma | pt_BR |
Subject | U-937 | pt_BR |
Subject | integrins | pt_BR |
Subject | extracellular matrix | pt_BR |
Subject | Fibronectin | pt_BR |
Subject | lymph nodes | pt_BR |
DeCS | Integrinas | pt_BR |
DeCS | Linfoma Difuso de Grandes Células B | pt_BR |
e-ISSN | 1791-2423 | |