Author | Dardenne, Mireille | |
Author | Smaniotto, Salete | |
Author | Coelho, Valéria de Mello | |
Author | Vila-Verde, Déa Maria Serra | |
Author | Savino, Wilson | |
Access date | 2018-08-16T17:01:23Z | |
Available date | 2018-08-16T17:01:23Z | |
Document date | 2009 | |
Citation | DARDENNE, Mireille; et al. Growth Hormone Modulates Migration of Developing T Cells. Neuroimmunomodulation, v.1153, p.1-5, 2009. | pt_BR |
ISSN | 1021-7401 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28193 | |
Language | eng | pt_BR |
Publisher | Karger Publishers | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Migração de timócitos | pt_BR |
Subject in Portuguese | epitélio tímico | pt_BR |
Subject in Portuguese | Hormônio do Crescimento | pt_BR |
Title | Growth Hormone Modulates Migration of Developing T Cells | pt_BR |
Type | Article | pt_BR |
Abstract | In the context of the cross-talk between the neuroendocrine and immune systems, it
is well known that growth hormone (GH) exerts physiological effects in central as well
as peripheral compartments of the immune system. GH modulates a variety of thymic
functions. For example, GH upregulates proliferation of thymocytes and thymic epithelial
cells. Accordingly, GH-transgenic mice, as well as animals and humans treated with
exogenous GH, exhibit an enhanced cellularity in the thymus organ. GH also stimulates
the secretion of thymic hormones, cytokines, and chemokines by the thymic microenvironment
as well as the production of extracellularmatrix proteins. These effects lead
to an increase in thymocyte migratory responses and intrathymic traffic of developing
T cells, including the export of thymocytes from the thymus organ, as ascertained
by experimental studies with intrathymic injection of GH in normal mice and with
GH-transgenic animals. Because GH promotes a replenishment of the thymus and an
increase of thymocyte export, it has been applied as a potential adjuvant therapeutic
agent in the treatment of immunodeficiencies associated with thymic atrophy. | pt_BR |
Affilliation | Universit´e Paris Descartes. Centre National de la Recherche Scientifique. Paris, France. | pt_BR |
Affilliation | Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Imunohistologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Departamento de Imunofisiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | GH | pt_BR |
Subject | IGF-1 | pt_BR |
Subject | thymic epithelium | pt_BR |
Subject | thymocyte migration | pt_BR |
DeCS | Fator de Crescimento Insulin-Like I | pt_BR |
e-ISSN | 1423-0216 | |
Embargo date | 2030-01-01 | |