Author | Kikuti, Mariana | |
Author | Tauro, Laura Beatriz | |
Author | Moreira, Patrícia Sousa dos Santos | |
Author | Campos, Gúbio Soares | |
Author | Paploski, Igor Adolfo Dexheimer | |
Author | Weaver, Scott C | |
Author | Reis, Mitermayer Galvão dos | |
Author | Kitron, Uriel | |
Author | Ribeiro, Guilherme de Sousa | |
Access date | 2018-08-07T13:27:31Z | |
Available date | 2018-08-07T13:27:31Z | |
Document date | 2018 | |
Citation | KIKUTI, M. et al. Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection. Virology Journal, v. 15, p. 108, 2018. | pt_BR |
ISSN | 1743-422X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27974 | |
Sponsorship | Research Ethics Committee at the Gonçalo Moniz Institute, Oswaldo Cruz Foundation | pt_BR |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika virus | pt_BR |
Subject in Portuguese | Sensibilidade e especificidade | pt_BR |
Subject in Portuguese | Ensaio imunoenzimático | pt_BR |
Subject in Portuguese | Imunoglobulina M | pt_BR |
Subject in Portuguese | Imunoglobulina G | pt_BR |
Title | Diagnostic performance of commercial IgM and IgG enzyme-linked immunoassays (ELISAs) for diagnosis of Zika virus infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12985-018-1015-6 | |
Abstract | Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses. Objective: To evaluate the sensitivity and specificity of commercial ZIKV IgM and IgG enzyme-linked immunoassay
(ELISA) kits.
Methods: We used sera from febrile patients with RT-PCR-confirmed ZIKV infection to determine sensitivity and
sera from RT-PCR-confirmed dengue cases and blood donors, both of which were collected before ZIKV epidemics
in Brazil (2009–2011 and 2013, respectively) to determine specificity.
Results: The ZIKV IgM-ELISA positivity among RT-PCR ZIKV confirmed cases was 0.0% (0/14) and 12.5% (1/8) for
acute- and convalescent-phase sera, respectively, while its specificity was 100.0% (58/58) and 98.3% (58/59) for
acute- and convalescent-phase sera of dengue patients, and 100.0% (23/23) for blood donors. The ZIKV IgG-ELISA
sensitivity was 100.0% (6/6) on convalescent-phase sera from RT-PCR confirmed ZIKV patients, while its specificity
was 27.3% (15/55) on convalescent-phase sera from dengue patients and 45.0% (9/20) on blood donors’ sera. The
ZIKV IgG-ELISA specificity among dengue confirmed cases was much greater among patients with primary dengue
(92.3%; 12/13), compared to secondary dengue (7.1%; 3/42).
Conclusions: In a setting of endemic dengue transmission, the ZIKV IgM-ELISA had high specificity, but poor
sensitivity. In contrast, the ZIKV IgG-ELISA showed low specificity, particularly for patients previously exposed to
dengue infections. This suggests that this ZIKV IgM-ELISA is not useful in confirming a diagnosis of ZIKV infection in
suspected patients, whereas the IgG-ELISA is more suitable for ZIKV diagnosis among travelers, who reside in areas
free of flavivirus transmission, rather than for serosurveys in dengue-endemic areas. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Medicina Tropical CONICET. Puerto Iguazu, Misiones, Argentina | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Texas Medical Branch. Galveston, TX, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, GA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Zika virus | pt_BR |
Subject | Sensitivity and specificity | pt_BR |
Subject | Enzyme-linked immunosorbent assay | pt_BR |
Subject | Immunoglobulin M | pt_BR |
Subject | Immunoglobulin G | pt_BR |