Author | Ballif, Marie | |
Author | Nhandu, Venerandah | |
Author | Wood, Robin | |
Author | Dusingize, Jean Claude | |
Author | Carter, E. Jane | |
Author | Cortes, Claudia P. | |
Author | McGowan, Catherine C. | |
Author | Diero, Lameck | |
Author | Graber, Claire | |
Author | Renner, Lorna | |
Author | Hawerlander, Denise | |
Author | Kiertiburanakul, Sasisopin | |
Author | Tuan Du, Quy | |
Author | Sterling, Timothy R. | |
Author | Egger, Matthias | |
Author | Fenner, Lukas | |
Author | For the International Epidemiological Databases to Evaluate AIDS (IeDEA) | pt_BR |
Access date | 2018-08-03T18:25:38Z | |
Available date | 2018-08-03T18:25:38Z | |
Document date | 2014 | |
Citation | BALLIF, Marie et al. Detection and management of drug-resistant tuberculosis in HIV-infected patients from lower income countries. International Journal of Tuberculosis and Lung Disease, v. 18, n. 11, p. 1327–1336, 2014. | pt_BR |
ISSN | 1027-3719 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27848 | |
Description | The IeDEA Caribbean, Central- and South America region
Primary investigators: Beatriz Grinsztejn (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil) | pt_BR |
Language | eng | pt_BR |
Rights | restricted access | pt_BR |
Title | Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries | pt_BR |
Type | Article | pt_BR |
DOI | 10.5588/ijtld.14.0106 | |
Abstract | Setting—Drug resistance threatens tuberculosis (TB) control, particularly among HIV-infected
persons.
Objective—We surveyed antiretroviral therapy (ART) programs from lower-income countries on
prevention and management of drug-resistant TB.
Design—We used online questionnaires to collect program-level data in 47 ART programs in
Southern Africa (14), East Africa (8), West Africa (7), Central Africa (5), Latin America (7) and
Asia-Pacific (6 programs) in 2012. Patient-level data were collected on 1,002 adult TB patients
seen at 40 of the participating ART programs.
Results—Phenotypic drug susceptibility testing was available at 36 (77%) ART programs, but
only used for 22% of all TB patients. Molecular drug resistance testing was available at 33 (70%) programs and used for 23% of all TB patients. Twenty ART programs (43%) provided directly
observed therapy (DOT) during the whole treatment, 16 (34%) during intensive phase only and 11
(23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line TB
regimens; 18 (38%) reported TB drug shortages.
Conclusions—Capacity to diagnose and treat drug-resistant TB was limited across ART
programs in lower income countries. DOT was not always implemented and drug supply was
regularly interrupted, which may contribute to the global emergence of drug resistance. | pt_BR |
Affilliation | Institute of Social and Preventive Medicine, University of Bern, Switzerland | pt_BR |
Affilliation | Centre for Infectious Disease Research in Zambia, Lusaka, Zambia | pt_BR |
Affilliation | Desmond Tutu HIV Centre, University of Cape Town, South Africa | pt_BR |
Affilliation | Women’s Equity in Access to Care & Treatment, Kigali, Rwanda | pt_BR |
Affilliation | USAID AMPATH, Eldoret, Kenya | pt_BR |
Affilliation | University of Chile School of Medicine, Santiago, Chile | pt_BR |
Affilliation | Vanderbilt University School of Medicine, Nashville, Tennessee, USA | pt_BR |
Affilliation | USAID AMPATH, Eldoret, Kenya | pt_BR |
Affilliation | Institute of Social and Preventive Medicine, University of Bern, Switzerland | pt_BR |
Affilliation | University of Ghana Medical School, Accra, Ghana | pt_BR |
Affilliation | Centre Intégré de Recherches Biocliniques, Abidjan, Côte d’Ivoire | pt_BR |
Affilliation | Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand | pt_BR |
Affilliation | Children’s Hospital, Ho Chi Minh City, Vietnam | pt_BR |
Affilliation | Swiss Tropical and Public Health Institute, University of Basel, Switzerland | pt_BR |
Subject | MDR-TB | pt_BR |
Subject | ART programs | pt_BR |
Subject | Africa | pt_BR |
Subject | Asia | pt_BR |
Subject | Latin America | pt_BR |
Embargo date | 2500-12-31 | |