Author | Oliveira, Patricia Ribeiro de | |
Author | Yamamoto, Aparecida Yulie | |
Author | Souza, Cleonice Barbosa Sandoval de | |
Author | Araújo, Natalia Motta de | |
Author | Gomes, Selma de Andrade | |
Author | Heck, Anália Ribeiro | |
Author | Figueiredo, José Fernando de Castro | |
Author | Mussi-Pinhata, Marisa Márcia | |
Access date | 2018-07-30T17:18:29Z | |
Available date | 2018-07-30T17:18:29Z | |
Document date | 2009 | |
Citation | OLIVEIRA, Patricia Ribeiro de et al. Hepatitis B viral markers in banked human milk before and after Holder pasteurization. Journal of Clinical Virology, v. 45, n. 4, p. 281–284, 2009. | pt_BR |
ISSN | 1386-6532 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27717 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Vírus da Hepatite B | pt_BR |
Subject in Portuguese | Mulheres lactantes | pt_BR |
Subject in Portuguese | Doador de leite humano | pt_BR |
Subject in Portuguese | Banco de leite humano | pt_BR |
Title | Hepatitis B viral markers in banked human milk before and after Holder pasteurization | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jcv.2009.04.003 | |
Abstract | Background: Blood screening for hepatitis B virus (HBV) is not universally performed for donor selection in human milk banks. Objectives: To evaluate the frequency of detection of HBV surface antigen (HBsAg) and HBV-DNA in colostrum of HBV-infected nursing mothers before and after Holder pasteurization. Study design: Forty-two concentrated breast milksampleswere obtained withintwo postnatalweeks from 24 HBsAg-positive women (4 HBeAg-positive and 20 HBeAg-negative, anti-HBe-positive) were tested for the presence of HBsAg and HBV-DNA before and after Holder pasteurization (30 min at 62.5 ◦C). Results: Before pasteurization, HBsAg and HBV-DNA were found in 14/24 (58%), and 20/24 (75%) first milk samples, respectively, obtained by 4 days after delivery. At least one marker was detected in 20/24 (83%) milk samples. Both markers were identified in milk of HBeAg-positive mothers, and most mothers with anti-HBe in blood had at least one HBV marker. Once detected, viral markers were frequently found in milk samples subsequently obtained from the same woman. Holder pasteurization did not affect the probability of detecting HBsAg (8/18, 44%), HBV-DNA (12/18, 67%), or at least one of them (15/18, 83%). Conclusions: Although the biological implications of these findings remain to be determined, considering that HBV is highly contagious and most recipients of banked human milk are preterm infants, these findings should be taken into account when donors are enlisted for human milk banks without serological screening. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto. SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto. SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto. SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital Universitário. Banco de Leite Humano. Ribeirão Preto, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Interna. Ribeirão Preto. SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto. SP, Brasil. | pt_BR |
Subject | hepatitis B virus | pt_BR |
Subject | Human milk donor | pt_BR |
Subject | Human milk bank | pt_BR |
Subject | Lactating women | pt_BR |
e-ISSN | 1873-5967 | |
Embargo date | 2030-01-01 | |