Author | Santos, Daniela | |
Author | Campos, Taís M | |
Author | Saldanha, Maíra | |
Author | Oliveira, Sergio Costa | |
Author | Nascimento, Mauricio | |
Author | Zamboni, Dario Simões | |
Author | Machado, Paulo Roberto | |
Author | Arruda, Sérgio Marcos | |
Author | Scott, Phillip | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Carvalho, Lucas Pedreira de | |
Access date | 2018-07-24T14:35:55Z | |
Available date | 2018-07-24T14:35:55Z | |
Document date | 2018 | |
Citation | SANTOS, D. et al. IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis. Journal of Investigative Dermatology, v. 138, p. 1107 e 1115, 2018. | pt_BR |
ISSN | 0022-202X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27625 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | Monócitos | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Title | IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jid.2017.11.029 | |
Abstract | Cutaneous leishmaniasis due to Leishmania braziliensis infection is an inflammatory disease in which skin ulcer development is associated with mononuclear cell infiltrate and high levels of inflammatory cytokine production. Recently, NLRP3 inflammasome activation and IL-1β production have been associated with increased pathology in murine cutaneous leishmaniasis. We hypothesized that cutaneous leishmaniasis patients have increased expression of NLRP3, leading to high levels of IL-1β production. In this article we show high production of IL-1β in biopsy samples and Leishmania antigen-stimulated peripheral blood mononuclear cells from patients infected with L. braziliensis and reduced IL-1β levels after cure. IL-1β production positively correlated with the area of necrosis in lesions and duration of the lesions. The main source of IL-1β was intermediate monocytes (CD14++CD16+). Furthermore, our murine experiments show that IL-1β production in response to L. braziliensis was dependent on NLRP3, caspase-1, and caspase-recruiting domain (ASC). Additionally, we observed an increased expression of the NLRP3 gene in macrophages and the NLRP3 protein in intermediate monocytes from cutaneous leishmaniasis patients. These results identify an important role for human intermediate monocytes in the production of IL-1β, which contributes to the immunopathology observed in cutaneous leishmaniasis patients. | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biquímica e Imunologia. Belo Horizont, MG, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biologia Celular. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Pennsylvania. Department of Pathobiology. Philadelphia, Pennsylvania, USA | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil | pt_BR |
Subject | Cutaneous Leishmaniasis | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Monocytes | pt_BR |
Subject | Infection | pt_BR |
Subject | Human | pt_BR |