Author | Matta, Nubia Estela | |
Author | Nogueira, Ricardo S. | |
Author | Franco, Antonia Maria Ramos | |
Author | Souza, Ilner de Souza e | |
Author | Mattos, Marise S. | |
Author | Oliveira Neto, Manoel P. | |
Author | Coutinho, Sergio G. | |
Author | Leon, Leonor L. | |
Author | Cruz, Alda Maria da | |
Access date | 2018-07-17T13:53:48Z | |
Available date | 2018-07-17T13:53:48Z | |
Document date | 2009 | |
Citation | MATTA, Nubia Estela et al. Leishmania ( Viannia ) guyanensis Induces Low Immunologic Responsiveness in Leishmaniasis Patients from an Endemic Area of the Brazilian Amazon Highland. American Journal of Tropical Medicine and Hygiene, v. 80, n. 3, p. 339-344, 2009. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27563 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Leishmania (Viannia) guyanensis | pt_BR |
Subject in Portuguese | Áreas endêmicas | pt_BR |
Subject in Portuguese | Baixa responsividade imunológica | pt_BR |
Subject in Portuguese | Amazônia Brasileira | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Title | Leishmania (Viannia) guyanensis Induces Low Immunologic Responsiveness in Leishmaniasis Patients from an Endemic Area of the Brazilian Amazon Highland | pt_BR |
Type | Article | pt_BR |
Abstract | Cutaneous leishmaniasis caused by Leishmania ( Viannia ) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoproliferative responses (LPRs) to Leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lymphocytes, mainly TCD4 + . High and low interferon (IFN)-g producers were observed. TNF-a, interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to L. braziliensis patients. CL caused by L. braziliensis presented positive LPRs and higher IFN-g production but undetectable IL-5. L. guyanensis seems to induce a down-regulation of the immune system compared with L. braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Pesquisas da Amazônia. Departamento de Ciências da Saúde. Divisão de Parasitologia I. Laboratório de Leishmanioses e Doença de Chagas. Manus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Faculdade de Ciências da Saúde. Departamento de Saúde Coletiva. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmania ( Viannia ) guyanensis | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Endemic Area | pt_BR |
Subject | Brazilian Amazon | pt_BR |
Subject | Low Immunologic Responsiveness | pt_BR |
e-ISSN | 1476-1645 | |