Author | Bello, Gonzalo | |
Author | Casado, Concepción | |
Author | Sandonis, Virginia | |
Author | Alvaro-Cifuentes, Tamara | |
Author | Santos, Caio A. Rodrigues dos | |
Author | García, Soledad | |
Author | Rodríguez, Carmen | |
Author | Del Romero, Jorge | |
Author | Pilotto, Jose H. | |
Author | Grinsztejn, Beatriz | |
Author | Veloso, Valdiléa G. | |
Author | Morgado, Mariza G. | |
Author | López-Galíndez, Cecilio | |
Access date | 2018-07-05T15:41:01Z | |
Available date | 2018-07-05T15:41:01Z | |
Document date | 2007 | |
Citation | BELLO, Gonzalo et al. Plasma Viral Load Threshold for Sustaining Intrahost HIV Type 1 Evolution. AIDS Research and Human Retroviruses, v. 23, n. 10, p. 1242-1250, 2007. | pt_BR |
ISSN | 0889-2229 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27320 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert | pt_BR |
Rights | restricted access | |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | carga viral plamática | pt_BR |
Subject in Portuguese | HIV tipo 1 intra-hospedeiro | pt_BR |
Title | Plasma viral load threshold for sustaining intrahost HIV type 1 evolution | pt_BR |
Type | Article | |
DOI | 10.1089/aid.2007.0074 | |
Abstract | The objective of the present study was to determine if natural suppression of plasma viremia below the detection limit of commercial assays (50-80 copies HIV-1 RNA/ml) can contain the HIV-1 evolution. HIV-1 quasispecies complexity in PBMC DNA was assessed in the env gene at two time points in 14 long-term nonprogressors (LTNPs). Sequence changes consistent with viral evolution was found in all patients with a median plasma RNA viral load >100 copies/ml. Evidence of low-level viral evolution was detected in two of four patients with intermittent viremia and a median plasma HIV-1 RNA load of >80 copies/ml. No significant evolution was observed in the three LTNPs with persistent viral suppression below the detection limit. Overall, a significant positive correlation (p < 0.001) was observed between viral evolution and plasma RNA viral load in the LTNPs analyzed. These results suggest that the detection limit of ultrasensitive viremia assays could represent an important threshold below which intrahost HIV-1 evolution does not occur. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain. | pt_BR |
Affilliation | Centro Sanitario Sandoval. IMSALUD. Comunidad Autónoma de Madrid. Madrid, Spain. | pt_BR |
Affilliation | Centro Sanitario Sandoval. IMSALUD. Comunidad Autónoma de Madrid. Madrid, Spain. | pt_BR |
Affilliation | Centro Sanitario Sandoval. IMSALUD. Comunidad Autónoma de Madrid. Madrid, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | HIV Type 1 | pt_BR |
Subject | Plasma | pt_BR |
Subject | Viral Load | pt_BR |
Subject | Intrahost HIV Type 1 Evolution | pt_BR |
e-ISSN | 1931-8405 | |
Embargo date | 2030-01-01 | |