Author | Carneiro Neto, Jose Abraão | |
Author | Santos, Silvane Braga | |
Author | Orge, Gloria Orge | |
Author | Tanajura, Davi | |
Author | Passos, Lucia | |
Author | Oliveira, Cassius José | |
Author | Andrade, Rosana | |
Author | Melo, Cláudio Galeno de | |
Author | Barroso, Ubirajara | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2018-06-26T17:55:09Z | |
Available date | 2018-06-26T17:55:09Z | |
Document date | 2018 | |
Citation | CARNEIRO NETO, J. A. et al. Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder. Brazilian Journal of Infectious Diseases, v. 22, n. 2, p. 79–84, 2018. | pt_BR |
ISSN | 1413-8670 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27131 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Bexiga hiperativa | pt_BR |
Subject in Portuguese | Toxina onabotulínica | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Title | Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bjid.2017.10.009 | |
Abstract | To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL). Methods: Case series with 10 patients with overactive bladder refractory to conservativetreatment with anticholinergic or physical therapy. They received 200Ui of onabotulinum-toxin type A intravesically and were evaluated by overactive bladder symptoms score(OABSS) and King’s Health Questionnaire.Results: The mean (SD) of the age was 52 + 14.5 years and 60% were female. All of them hadconfirmed detrusor overactivity on urodynamic study. Seven patients had HAM/TSP. Themedian and range of the OABSS was 13 (12–15) before therapy and decreased to 1.0 (0–12)on day 30 and to 03 (0–14) on day 90 (p < 0.0001). There was a significant improvement in 8 ofthe 9 domains of the King’s Health Questionnaire after the intervention. Hematuria, urinaryretention and urinary infection were the complications observed in 3 out of 10 patients. Themean time to request retreatment was 465 days.Conclusion: Onabotulinum toxin type A intravesically reduced the OABSS with last long effectand improved the quality of life of HTLV-1 infected patients with severe overactive bladder. | pt_BR |
Affilliation | Universidade Federal da Bahia. Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Urologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Urologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Urologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenc¸as Tropicais. Salvador, BA, Brasil | pt_BR |
Subject | Overactive bladder | pt_BR |
Subject | Onabotulinum toxin | pt_BR |
Subject | HTLV-1 | pt_BR |