Author | Delatorre, Edson | |
Author | Jesus, Carlos Silva de | |
Author | Fernandez, José Carlos Couto | |
Author | Pilotto, Jose H. | |
Author | Morgado, Mariza G. | |
Access date | 2018-06-19T11:21:54Z | |
Available date | 2018-06-19T11:21:54Z | |
Document date | 2017 | |
Citation | DELATORRE, Edson; et al. High HIV-1 Diversity and Prevalence of Transmitted Drug Resistance Among Antiretroviral-Naive HIV-Infected Pregnant Women from Rio de Janeiro, Brazil. Aids Research and Human Retroviruses, v.00, n.00, 6p, 2016. | pt_BR |
ISSN | 0889-2229 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26937 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Grávidas | pt_BR |
Subject in Portuguese | Transmissão | pt_BR |
Subject in Portuguese | Resitência a medicamentos | pt_BR |
Subject in Portuguese | Rio de Janeiro | pt_BR |
Subject in Portuguese | Prevalência | pt_BR |
Title | High HIV-1 Diversity and Prevalence of Transmitted Drug Resistance Among Antiretroviral-Naive HIV-Infected Pregnant Women from Rio de Janeiro, Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/AID.2016.0159 | |
Abstract | Antiretroviral (ARV) resistance mutations in human immunodeficiency virus type 1 (HIV-1) infection may reduce the efficacy of prophylactic therapy to prevent mother-to-child transmission (PMTCT) and future treatment options. This study evaluated the diversity and the prevalence of transmitted drug resistance (TDR) in protease (PR) and reverse transcriptase (RT) regions of HIV-1 pol gene among 87 ARV-naive HIV-1-infected pregnant women from Rio de Janeiro, Brazil, between 2012 and 2015. The viral diversity comprised HIV-1 subtypes B (67.8%), F1 (17.2%), and C (4.6%); the circulating recombinant forms 12_BF (2.3%), 28/29_BF, 39_BF, 02_AG (1.1% each) and unique recombinants forms (4.5%). The overall prevalence of any TDR was 17.2%, of which 5.7% for nucleoside RT inhibitors, 5.7% for non-nucleoside RT inhibitors, and 8% for PR inhibitors. The TDR prevalence found in this population may affect the virological outcome of the standard PMTCT ARV-regimens, reinforcing the importance of continuous monitoring. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Pregnant Women | pt_BR |
Subject | Antiretroviral resistance | pt_BR |
Subject | Rio de Janeiro | pt_BR |
Subject | Prevalence | pt_BR |
e-ISSN | 1931-8405 | |
Embargo date | 2030-01-01 | |